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UnknownProtective Mechanism of Polygonum perfoliatum L. Extract on Chronic Alcoholic Liver Injury Based on UHPLC-QExactive Plus Mass Spectrometry Lipidomics and MALDI-TOF/TOF Mass Spectrometry Imaging.
Not available
S-EPMC9179971 | biostudies-literature
ProteomicsIdentification of Clostdridium difficile Immunoreactive Spore Proteins of the Epidemic strain R20291
Clostridium difficile infections are the leading cause of diarrhea associated to the use of antibiotics. During infection, C. difficile initiates a sporulation cycle leading to the persistence of C. difficile spores in the host and disease dissemination. Nowadays, the development of vaccine and pass...
ORGANISM(S): Peptoclostridium difficile (strain R20291) (Clostridium difficile) 
2018-07-05 | PXD008592 | Pride
Cdi patients Isoelectric focusing Spores Clostridium difficile Immunoblotting Two-dimensional electrophoresis Serologic reactivity 
ProteomicsThermococcus kodakarensis proteins expressed at various temperatures reveals changes in RNA modifications
Thermococcus kodakarensis is a thermophilic archaea used in this study to determine how changes in growth temperature affect protein expression. This organism was chosen, in part, due to the simplified proteome and potential protein stability gained when analyzing proteins at room temperature. Two t...
ORGANISM(S): Thermococcus kodakarensis KOD1 
2020-02-17 | PXD014814 | Pride
Proteomics Thermococcus kodakarensis Theromphile Qexactive plus 
ProteomicsComparative proteomics for identification of type I interferon response in primary human glioblastoma multiforme cells
Oncolytic virus therapy is a promising direction for cancer treatment. Numerous oncolytic virus strains are under development or examined in clinical trials, there are examples of FDA approved virus vaccines. Although evident progress exists, oncolytic viruses still suffer low efficiency and the mec...
ORGANISM(S): Homo sapiens (Human) 
2022-02-03 | PXD022906 | Pride
Glioblastoma Proteomics Interferone response Lc-ms/ms Oncolytic viruses 
UnknownShotgun proteomics data on the impact of hyperglycaemia on platelet protein acetylation by aspirin.
Not available
S-EPMC6288982 | biostudies-literature
Proteomics1-deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding
Ischemic heart disease and stroke are the most common causes of death world-wide. In both pathologies anoxia, the lack of oxygen, triggers profound metabolic and cellular changes. Sphingolipids have been implicated in anoxia injury, but the pathomechanism is unknown. Here we show that injury is caus...
ORGANISM(S): Caenorhabditis elegans 
2019-08-20 | PXD014573 | Pride
C. elegans Qexactive plus Lc-ms/ms 
MetabolomicsAntidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique p...
2019-05-24 | MTBLS836 | MetaboLights
MetabolomicsFDR-controlled metabolite annotation for high-resolution imaging mass spectrometry imaging MS (LC-MS assay)
High-mass-resolution imaging mass spectrometry promises to localize hundreds of metabolites directly from tissues, cell cultures, and agar plates with cellular resolution, but is hampered by the lack of bioinformatics for automated metabolite identification. We developed the first bioinformatics fra...
2016-12-05 | MTBLS378 | MetaboLights
ProteomicsComparative proteomics for identification of type I interferon response in primary human glioblastoma multiforme cells
Oncolytic virus therapy is a promising direction for cancer treatment. Numerous oncolytic virus strains are under development or examined in clinical trials, there are examples of FDA approved virus vaccines. Although evident progress exists, oncolytic viruses still suffer low efficiency and the mec...
ORGANISM(S): Homo sapiens (Human) 
2022-02-03 | PXD022836 | Pride
Glioblastoma Proteomics Interferone response Lc-ms/ms Oncolytic viruses 
ProteomicsCD22 interactome
CD22 (Siglec-2) is a member of the Siglec family. It is an inhibitory co-receptor of the B-cell-receptor (BCR) and inhibits B–cell activation. Upon BCR stimulation ITIMs in the cytoplasmic tail of CD22 are phosphorylated. This triggers CD22 signalling pathways, which lead to a decreased calcium mobi...
ORGANISM(S): Gallus gallus (Chicken) 
2020-05-06 | PXD013801 | Pride
Cullin 3 Silac B cells Cd22 Qexactive plus Dt40 cells 
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