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TranscriptomicsSequence, Biogenesis, and Function of Diverse sRNA Classes Bound to the Piwi-family Proteins of Tetrahymena thermophila
PAZ/PIWI-domain (PPD) proteins carrying small RNAs (sRNAs) function in gene and genome regulation. The ciliate Tetrahymena thermophila encodes numerous PPD proteins exclusively of the Piwi clade. We show that the three Tetrahymena Piwi-family proteins (Twis) preferentially expressed in growing cells...
ORGANISM(S): Tetrahymena thermophila 
2009-11-23 | E-GEOD-17006 | biostudies-arrayexpress
ProteomicsStructure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating membrane drug targets that cannot be fully inhibited using traditional inhibitors. Several ingenious chimeras have been developed...
ORGANISM(S): Homo Sapiens 
2025-03-04 | PXD061425 |
ProteomicsLarge bidirectional remodeling of the Myc-induced cell surface proteome in B-cells and prostate cells creates new opportunities for immunotherapy
To identify how MYC overexpression remodels the cell surface proteome in a cell autologous fashion and in different cell types, we investigated the impact of MYC overexpression on ~800 surface proteins in three isogenic model cell lines either of B-cell or prostate cell origin that were engineered t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-07 | MSV000085930 | MassIVE
ProteomicsSensitive profiling of cell surface proteome by using an optimized biotinylation method
Sensitive profiling of cell surface proteome by using an optimized biotinylation method
ORGANISM(S): Homo Sapiens (human) 
2023-02-02 | PXD039794 | JPOST Repository
ProteomicsRepurposing E3 ubiquitin ligases as cell surface protein degraders using Proteolysis Targeting Antibodies
The majority of current therapeutics targeting plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. Typical mammalian proteins, however, consist of multiple domains executing discrete but coordinated activities, and saturating inhibition of one functional domain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089542 | MassIVE
ProteomicsGrowth condition-dependent cell surface proteome analysis of Enterococcus faecium
Using a proteolytic shaving approach we identified differentially expressed surface exposed proteins of E. faecium cells after growth in different conditions.
ORGANISM(S): Enterococcus Faecium E1162 (ncbitaxon:535206) 
2015-07-07 | MSV000079184 | MassIVE
TranscriptomicsYeast Membrane Bound Polysome
Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. mRNA species bound to membrane-associated polysomes were separated from other mRNAs by sedimentation equilibrium or sedimentation velocity. The distribution of individual transcripts in the 'membran...
ORGANISM(S): Saccharomyces cerevisiae 
2005-08-24 | E-GEOD-3180 | biostudies-arrayexpress
TranscriptomicsTransport of influenza A virus neuraminidase to host cell surface and virus replication are regulated by ARHGAP21 and Cdc42
Influenza virus neuraminidase (NA), a type II transmembrane glycoprotein, is transported to the virus assembly site at the plasma membrane and is a major viral envelope component that plays a critical role in the release of progeny virions and in determination of host range restriction. Although sig...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-32878 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Streptomyces coelicolor mutant unable to erect aerial hyphae identifies a previously unknown layer of erial mycelium surface proteins (the "chaplins")
The filamentous bacterium Streptomyces coelicolor differentiates by forming specialized, spore-bearing aerial hyphae that grow into the air. Using microarrays, we identified genes that are down-regulated in a mutant unable to erect aerial hyphae. Through this route, we identified a previously unkno...
ORGANISM(S): Streptomyces coelicolor 
2007-06-11 | E-SMDB-4093 | biostudies-arrayexpress
OtherQuantitative Proteomic Verification of Membrane Proteins as Potential Therapeutic Targets Located in the 11q13 Amplicon in Cancers.
Data from ProteomeXchange, PXD ID: PXD002486. Experiment: 11q13_group3_HHn1, file: folder summary. Published as part of J Proteome Res. 2015 Jul 29 . From the Abstract: {{i}} ... We employed a tandem mass spectrometry proteomics approach using tumor cell lines to identify the cell surface proteins ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320017500 | GPMDB
Resource Reanalysis 
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