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ProteomicsMiR-29 coordinates age-dependent plasticity brakes in the adult visual cortex
Visual cortical circuits show profound plasticity during early life and are later stabilized by molecular "brakes" limiting excessive circuit rewiring beyond a critical period. How the appearance of these factors is coordinated during the transition from development to adulthood remains unknown. We ...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-04 | PXD016430 | Pride
Age-dependent plasticity Mir-29 Visual cortex 
ProteomicsMiR-29 coordinates age-dependent plasticity brakes in the adult visual cortex
Visual cortical circuits show profound plasticity during early life and are later stabilized by molecular "brakes" limiting excessive circuit rewiring beyond a critical period. How the appearance of these factors is coordinated during the transition from development to adulthood remains unknown. We ...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-04 | PXD016358 | Pride
Age-dependent plasticity Mir-29 Visual cortex 
ProteomicsReduced proteasome activity in the aging brainresults in ribosome stoichiometry loss and aggregation
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived vertebrate Nothobranchius furzeri combining transcriptomics and proteomics. We ...
ORGANISM(S): Nothobranchius furzeri 
2020-06-19 | PXD012314 | Pride
Brain Proteasome activity Ribosome stoichiometry Aging Aggregation 
TranscriptomicsRNA-seq of the brain of Nothobranchius furzeri at different time points
Background: Comparison of temporal gene expression profiles (www.jenage.de) The RNA-seq data comprises 5 age groups: 5,12,20,27,39 weeks 25 samples: 5 biological replicates for each age group
ORGANISM(S): Nothobranchius furzeri 
2014-07-29 | E-GEOD-52462 | biostudies-arrayexpress
ProteomicsReconnecting Vagus Nerve to the Heart through Nerve Conduit Preserves Cardiac Function in a Minipig Model of Right Cardiac Vagotomy
The right vagus nerve (RVN) plays a crucial role in maintaining cardiac homeostasis, and its intrathoracic resection leads to postoperative cardiac complications. Developing effective method to repair the RVN after surgical transection at the heart level is a critical unmet clinical need. Here we sh...
ORGANISM(S): Sus Scrofa (ncbitaxon:9823) 
2025-10-05 | MSV000099384 | MassIVE
ProteomicsReduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived vertebrate Nothobranchius furzeri combining transcriptomics and proteomics. We ...
ORGANISM(S): Struthio camelus (Ostrich) Pisum sativum (Garden pea) Mus musculus (Mouse) Olea europaea (Common olive) Nothobranchius furzeri Vigna mungo (Rice bean) (Black gram) Pongo pygmaeus (Bornean orangutan) Sus scrofa domesticus (domestic pig) Merluccius bilinearis (Silver hake) Rattus rattus (Black rat) Mesocricetus auratus (Golden hamster) Zea mays (Maize) Rattus norvegicus (Rat) Taeniopygia guttata (Zebra finch) (Poephila guttata) Pan troglodytes (Chimpanzee) Trypanosoma brucei Pinus radiata (Monterey pine) Nicotiana tabacum (Common tobacco) Oryza sativa (Rice) Vitis vinifera (Grape) Ricinus communis Solanum tuberosum (Potato) Triticum aestivum (Wheat) Saccharomyces cerevisiae (Baker's yeast) Yarrowia lipolytica (Candida lipolytica) Xenopus laevis (African clawed frog) Staphylococcus aureus 
2020-06-22 | PXD016587 | Pride
Transcriptome Brain Ribosome Aging Protein complex Proteasome Stoichiometry Proteome Aggregation 
ProteomicsReduced proteasome activity in the aging brainresults in ribosome stoichiometry loss and aggregation
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived vertebrate Nothobranchius furzeri combining transcriptomics and proteomics. We ...
ORGANISM(S): Mus musculus (Mouse) Nothobranchius furzeri 
2020-08-17 | PXD018399 | Pride
Proteasome activity Aging brain Ribosome stoichiometry Aggregation 
ProteomicsTHE AGING SYNAPSE: AN INTEGRATED PROTEOMIC AND TRANSCRIPTOMIC ANALYSIS.
An important hallmark of aging is the loss of proteostasis, which can lead to the formation of protein aggregates and mitochondrial dysfunction in neurons. Although it is well known that protein synthesis is finely regulated in the brain, especially at synapses, where mRNAs are locally translated in...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-10-14 | MSV000096075 | MassIVE
ProteomicsReduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived vertebrate Nothobranchius furzeri combining transcriptomics and proteomics. We ...
ORGANISM(S): Nothobranchius furzeri 
2020-06-22 | PXD016459 | Pride
Transcriptome Brain Ribosome Aging Protein complex Proteome Proteasome Aggregation Stoichiometry 
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