Sort   by:  
 Page size 
MetabolomicsCreatine uptake promotes dendritic cell activation and enhances antitumor immunity

Dendritic cells (DCs) are central regulators of antitumor T cell immunity and are highly sensitive to metabolic cues. However, the therapeutic potential of targeting DC metabolism remains underexplored. Here, we report upregulation of the creatine transporter (CrT; Slc6a8) in intratumora...

2026-03-11 | MTBLS12797 | MetaboLights
MetabolomicsMembrane lipid as cofactor of cargo uptake and release by box-like lipid transfer proteins
Lipid transfer proteins (LTPs) shuttle their cargo lipids between cellular membranes. LTPs facilitate the costly extraction of a lipid from a donor membrane, and its delivery into the acceptor membrane, but the mechanisms remain poorly understood. We combined extensive molecular dynamics simulations...
2026-10-06 | MTBLS15933 | MetaboLights
TranscriptomicsWRKY6 Transcription Factor Restricts Arsenate Uptake and Transposon Activation in Arabidopsis
Stress constantly challenges plant adaptation to the environment. Of all stress types, arsenic was a major threat during the early evolution of plants. The most prevalent chemical form of arsenic is arsenate, whose similarity to phosphate renders it easily incorporated into cells via the phosphate...
ORGANISM(S): Arabidopsis thaliana 
2014-04-25 | E-GEOD-49037 | biostudies-arrayexpress
GenomicsMetabolic Programming Promotes Cellular Uptake of Extracellular Vesicles and Boosts In Vivo Therapeutic Efficacy
Metabolic Programming Promotes Cellular Uptake of Extracellular Vesicles and Boosts In Vivo Therapeutic Efficacy
PRJNA1391512 | ENA
ProteomicsTuning Liposome Composition to Modulate the Corona Forming in Human Serum and Uptake by Cells
Nano-sized objects such as liposomes are modified by adsorption of biomolecules in biological fluids. The resulting corona critically changes nanoparticle behavior at cellular level. A better control of corona composition could allow to modulate uptake by cells. Within this context, in this work, li...
ORGANISM(S): Homo sapiens (Human) 
2020-02-28 | PXD017776 | Pride
Nanoparticle corona Human serum Liposomes Cellular uptake 
TranscriptomicsIron uptake experiments in yeast
The budding yeast S. cerevisiae responds to depletion of iron in the environment by activating Aft1p, the major iron-dependent transcription factor, and by transcribing systems involved in the uptake of iron. Here we have studied the transcriptional response to iron deprivation, and have identified ...
ORGANISM(S): Saccharomyces cerevisiae 
2006-02-07 | E-GEOD-4196 | biostudies-arrayexpress
TranscriptomicsPeturbation of PICALM Levels Alters Cellular Cholesterol Metabolism
PICALM (Phosphatidyl Inositol Clathrin Assembly Lymphoid Myeloid protein) is a ubiquitously expressed protein that plays a role in clathrin-mediated endocytosis. PICALM also affects the internalization of SNAREs and modulates macroautophagy. Chromosomal translocations that result in the fusion of PI...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-64855 | biostudies-arrayexpress
TranscriptomicsAdipose Rab10 Knockout Causes Insulin Resistance through Impaired Glucose Uptake
Insulin action in adipocytes affects whole-body insulin sensitivity. Studies of adipose-specific Glut4 knockout mice have established that adipose Glut4 contributes to the control of systemic glucose homeostasis. Presumably, this reflects a role for Glut4-mediated glucose transport in the regulation...
ORGANISM(S): Mus musculus 
2016-06-30 | E-GEOD-70123 | biostudies-arrayexpress
TranscriptomicsEffects of aneuploidy on cellular physiology and cell division in haploid yeast.
Aneuploidy is a condition frequently found in tumor cells but how it affects cellular physiology is not known. We have characterized one aspect of aneuploidy, the gain of extra chromosomes. We created a collection of haploid yeast strains that each bear an extra copy of one or more of almost all of ...
ORGANISM(S): Saccharomyces cerevisiae 
2007-05-17 | E-GEOD-7812 | biostudies-arrayexpress
Transcriptomics18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.
Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for th...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-21217 | biostudies-arrayexpress
Sort   by:  
 Page size