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TranscriptomicsInnate immune pathways in afferent lymph following vaccination with poly(I:C) -containing liposomes
Many modern vaccines use defined adjuvants to stimulate the innate immune system and shape the adaptive immune response. The exact nature of these innate signals and whether immune differentiation can originate within the periphery is not known. In the present study we used an ovine lymphatic cannul...
ORGANISM(S): Ovis aries 
2013-08-01 | E-GEOD-38533 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human A2780 ovarianc cancer cells and cisplatin resistant derivate cells treated with cisplatin or liposomal cisplatin
A2780 ovarian cancer cells and a cisplatin resistant derivate of A2780 cells, obtained from ECACC, UK, No. 93112519 [A2780] and No. 93112517 [A2780 cis] were seeded out in T-75 flasks at a density of 2x106 for A2780sens and 3x106 for A2780cis cells in 15 ml of medium and preincubated overnight. Medi...
ORGANISM(S): Homo sapiens 
2010-12-13 | E-MEXP-2840 | biostudies-arrayexpress
TranscriptomicsLow-power photodynamic therapy induces survival signaling in cultured hilar cholangiocarcinoma cells
Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizerreplete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and inducti...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-68292 | biostudies-arrayexpress
TranscriptomicsKupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity.
Kupffer cells have been implicated in the pathogenesis of various liver diseases. However, their involvement in metabolic disorders of the liver, including fatty liver disease, remains unclear. The present study sought to determine the impact of Kupffer cells on hepatic triglyceride storage and to e...
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-33044 | biostudies-arrayexpress
GenomicsEffect of free cholesterol on the inflammatory response induced by POPC liposomes
Effect of free cholesterol on the inflammatory response induced by POPC liposomes
PRJNA1423693 | ENA
TranscriptomicsRNAseq of liver dendritic cells targeted with empty liposomes or curcumin liposomes
Non-alcoholic fatty liver disease (NAFLD) is a common complication of obesity, where insulin resistance and hepatocyte fat deposition may progress to steatohepatitis (NASH) and fibrosis/ cirrhosis. NASH has no approved treatment. Consequent upon hepatic fat deposition, NF-κB activation in hepatic my...
ORGANISM(S): Mus musculus 
2020-01-22 | GSE94592 | GEO
GenomicsRNA-seq of human dendritic cells cultured with PSAB-liposomes and/or Liraglutide
RNA-seq of human dendritic cells cultured with PSAB-liposomes and/or Liraglutide
PRJNA603462 | ENA
ProteomicsTuning Liposome Composition to Modulate the Corona Forming in Human Serum and Uptake by Cells
Nano-sized objects such as liposomes are modified by adsorption of biomolecules in biological fluids. The resulting corona critically changes nanoparticle behavior at cellular level. A better control of corona composition could allow to modulate uptake by cells. Within this context, in this work, li...
ORGANISM(S): Homo sapiens (Human) 
2020-02-28 | PXD017776 | Pride
Nanoparticle corona Human serum Liposomes Cellular uptake 
ProteomicsIshikawa cell line LC-MS/MS analysis
The protein profile of Ishikawa cells, a widely used model for uterine lining cell studies, was examined. Additionally, we investigated potential disruptions caused by liposomes containing phosphatidylcholine and phosphatidylethanolamine, serving as models for drug delivery.
ORGANISM(S): Homo sapiens (Human) 
2024-08-17 | PXD050871 | Pride
Phosphatidylcholine Endometrial epithelial cells Proteomics Liposomes 
TranscriptomicsRNAseq of livers of mice fed high fat high sugar diet and either untreated or treated with curcumin liposomes or calcitriol liposomes
Non-alcoholic fatty liver disease (NAFLD) is a common complication of obesity, where insulin resistance and hepatocyte fat deposition may progress to steatohepatitis (NASH) and fibrosis/ cirrhosis. NASH has no approved treatment. Consequent upon hepatic fat deposition, NF-κB activation in hepatic my...
ORGANISM(S): Mus musculus 
2020-01-22 | GSE94593 | GEO
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