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ProteomicsNdfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
Project abstract: Foxp3+ T regulatory (Treg) cells have important functions in suppressing immune cell activation and establishing normal immune homeostasis. How Treg cells maintain their identity is not completely understood. Here we show that Ndfip1, a co-activator of Nedd4-family E3 ubiquitin lig...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-19 | PXD006251 | Pride
Effector-type regulatory t cells (etreg cells) Ndfip1 Central regulatory t cells (ctreg cells) Regulatory t cells (treg cells) 
UnknownImpact of chronic alcohol exposure on conventional and regulatory murine T cell subsets.
Not available
S-EPMC10063870 | biostudies-literature
UnknownDevelopmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets.
Not available
S-EPMC4868642 | biostudies-literature
TranscriptomicsInterleukin-2 receptor signaling acts as a checkpoint that shapes the distribution of regulatory T cell subsets (scRNA-Seq)
Regulatory T cells (Tregs) require IL-2 for survival in the periphery, yet how IL-2 shapes Treg heterogeneity remains poorly defined. Here we found that inhibition of IL-2R signaling in post-thymic Tregs leads to a preferential early loss of central Tregs (cTregs). Gene expression of cTregs was more...
ORGANISM(S): Mus musculus 
2024-10-18 | GSE268022 | GEO
TranscriptomicsInterleukin-2 receptor signaling acts as a checkpoint that shapes the distribution of regulatory T cell subsets (RNA-Seq)
Regulatory T cells (Tregs) require IL-2 for survival in the periphery, yet how IL-2 shapes Treg heterogeneity remains poorly defined. Here we found that inhibition of IL-2R signaling in post-thymic Tregs leads to a preferential early loss of central Tregs (cTregs). Gene expression of cTregs was more...
ORGANISM(S): Mus musculus 
2024-10-18 | GSE268021 | GEO
GenomicsInterleukin-2 receptor signaling acts as a checkpoint that shapes the distribution of regulatory T cell subsets (scRNA-Seq)
Interleukin-2 receptor signaling acts as a checkpoint that shapes the distribution of regulatory T cell subsets (scRNA-Seq)
PRJNA1114065 | ENA
GenomicsInterleukin-2 receptor signaling acts as a checkpoint that shapes the distribution of regulatory T cell subsets (RNA-Seq)
Interleukin-2 receptor signaling acts as a checkpoint that shapes the distribution of regulatory T cell subsets (RNA-Seq)
PRJNA1114062 | ENA
GenomicsmTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis
mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis
PRJNA411780 | ENA
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