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ProteomicsThe Centriolar Satellite Component CEP131 timely regulates mitochondrial Apoptosis
Centriolar satellites are multiprotein aggregates that orbit the centrosome and govern centrosome homeostasis and primary cilia formation. In contrast to the scaffold PCM1, which nucleates centriolar satellites and has been linked to microtubule dynamics, autophagy, and intracellular trafficking, th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042470 | Pride
Mitochondria Centriolar satellites Cep131 Apoptosis 
UnknownCep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability.
Not available
S-EPMC6662699 | biostudies-literature
UnknownPolo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131).
Not available
S-EPMC6484138 | biostudies-literature
UnknownCEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma.
Not available
S-EPMC7512061 | biostudies-literature
Unknownp38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1.
Not available
S-EPMC4674683 | biostudies-literature
UnknownHepatic ARID3A facilitates liver cancer malignancy by cooperating with CEP131 to regulate an embryonic stem cell-like gene signature.
Not available
S-EPMC9411159 | biostudies-literature
UnknownAcute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.
Not available
S-EPMC3887133 | biostudies-literature
UnknownDilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formation.
Not available
S-EPMC3138703 | biostudies-literature
TranscriptomicsThe Unkempt RNA binding protein reveals a local translation program in centriole overduplication
Excess centrosomes cause defects in mitosis, cell-signaling, and cell migration, and therefore their assembly is tightly regulated. The divergent Polo kinase, PLK4, controls centriole duplication at the heart of centrosome assembly, and elevated PLK4 levels promote centrosome amplification (CA), a f...
ORGANISM(S): Homo sapiens 
2025-05-17 | GSE297133 | GEO
ProteomicsCDKL5 substrates - Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase
Identification of CDKL5 substrates. Immuno-precipitated proteins were TMT labelled and analysed via LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD009327 | Pride
Cdkl5 Tmt Dlg5 map1s Cep131 
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