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MetabolomicsComparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria

Malaria varies in severity, with complications ranging from uncomplicated to severe malaria. Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The metabolic interactions between the host and Plasmodium species are yet to be understood during these inf...

2022-09-14 | MTBLS4387 | MetaboLights
TranscriptomicsRNA-seq analysis of anti-malarial drug chemotherapy of murine experimental Cerebral Malaria (ECM)
Cerebral Malaria (HCM) is a serious neurological complication caused by Plasmodium falciparum infection. Currently the only treatment for HCM is the provision of anti-malarial drugs; however, such treatment by itself often fails to prevent death or development of neurological sequelae. To identify n...
ORGANISM(S): Mus musculus 
2018-07-03 | E-MTAB-6474 | biostudies-arrayexpress
ProteomicsCerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children
Clinically distinguishing acute bacterial meningitis from cerebral malaria, both of which are important causes of acute non-traumatic coma associated with morbidity and mortality among paediatric hospital admissions in malaria endemic areas of Africa, is challenging. Few hospitals have diagnostic ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-24 | MSV000080979 | MassIVE
TranscriptomicsTranscription profiling of genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains
Gene expression patterns were investigated in well-defined genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains. cDNA microarrays were used to search for differentially expressed genes in mouse brain. Four mouse strains, known to differ in susceptibilit...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-370 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cerebral malaria susceptible and resistant animals
Cerebral malaria (CM) is a leading cause of death in the world. Better understanding of the pathogenesis of this disease is critical for the development of novel therapies. In this work, we investigated temporal gene expression profiles in the brains of CM-susceptible and CM-resistant mice during in...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7814 | biostudies-arrayexpress
TranscriptomicsCommon Irf-regulated genomic responses drive pathological inflammation during experimental cerebral malaria as well as protective response against M. tuberculosis
Analysis of transcriptional response to Plasmodium berghei ANKA infection in cerebral malaria susceptible C57BL/6 mouse brains as well as cerebral malaria resistant BXH2 mice which carry a severe hypomorphic Irf8-R294C allele. Interferon Regulatory Factor 8 (IRF8) is required for development, matura...
ORGANISM(S): Mus musculus 
2015-01-16 | E-GEOD-65036 | biostudies-arrayexpress
TranscriptomicsPaired whole blood human transcription profiles from children with severe malaria and mild malaria
Whole blood transcriptomes from a longitudinal study of 5 Malawian children who first present with severe Plasmodium falciparum malaria, and return in one month with mild malaria We used microarrays to identify transcripts that were associated with each clinical presentation. A blood sample was tak...
ORGANISM(S): Homo sapiens 
2012-01-11 | E-GEOD-33811 | biostudies-arrayexpress
TranscriptomicsP. falciparum Complicated Malaria: Modulation and Connectivity between Exportome and Variant Surface Gene Families
In temperate and sub-tropical regions of Latin America, complicated malaria manifested as hepatic dysfunction or renal dysfunction is seen in all age groups. There has been a concerted focus on understanding the patho-physiological and molecular basis of complicated malaria in children, much less is...
ORGANISM(S): Plasmodium falciparum 
2015-07-07 | E-GEOD-59844 | biostudies-arrayexpress
TranscriptomicsCerebral malaria versus asymptomatic malaria
We hypothesized that differential gene expression contributes to phenotypic variation of parasites which results in specific interaction of Plasmodium falciparum with its human host. In this study we used microarray hybridization to analyse the transcriptomes of P.falciparum isolated from asymptoma...
ORGANISM(S): Plasmodium falciparum 
2014-12-01 | E-MTAB-2139 | biostudies-arrayexpress
TranscriptomicsInfection-induced resistance to experimental cerebral malaria
Cerebral malaria (CM) is one of the most severe complications of malaria infection. There is evidence that repeated parasite exposure promotes resistance against CM, as indicated by the low incidence of CM in adults in malaria-endemic regions. However, the immunological basis of this infection-induc...
ORGANISM(S): Mus musculus 
2019-02-19 | E-MTAB-5513 | biostudies-arrayexpress
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