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MetabolomicsA next-generation yeast chassis: comprehensive characterization of a robust fast-growing Saccharomyces cerevisiae

Robust and efficient hosts are necessary to facilitate advances in biotechnology. We unveil Saccharomyces cerevisiae strain XP as a promising new microbial chassis owing to its high growth rate and robustness. This strain has a doubling time of 48.2 min, which is 12.8 min faster than the...

2024-09-26 | MTBLS7328 | MetaboLights
MetabolomicsProteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation

Saccharomyces cerevisiae is a widely used cell factory; therefore, it is important to understand how it organizes key functional parts when cultured under different conditions. Here, we perform a multiomics analysis of S. cerevisiae by culturing the strain with a wide range of s...

2022-08-31 | MTBLS697 | MetaboLights
MetabolomicsComprehensive Untargeted Metabolomics Dataset of Saccharomyces cerevisiae Aging-Associated Mutants and Yeast–Host Interactions in Drosophila melanogaster

Aging is a complex biological process influenced by genetic factors, environmental conditions, and interactions between organisms and their associated microbes. The budding yeast Saccharomyces cerevisiae and the fruit fly Drosophila melanogaster provide complementary model systems for investigati...

2026-09-04 | MTBLS15555 | MetaboLights
MetabolomicsInvestigating uncharacterised genes in Saccharomyces cerevisiae using Robot Scientists

Despite extensive research on Saccharomyces cerevisiae functional genomics, approximately 880 out of ~6,000 open reading frames (ORFs) remain uncharacterised. In this study we propose a method for characterising genes with limited prior functional knowledge using an automated laboratory platform,...

2025-12-03 | MTBLS12663 | MetaboLights
MetabolomicsLinking genetic, metabolic and phenotypic diversity 1 among S. cerevisiae strains using multi-omics associations
The selection of bioengineering platform strains and engineering strategies to improve the stress resistance of Saccharomyces cerevisiae remains a pressing need in bio-based chemical production. Thus, a systematic effort to exploit the genotypic and phenotypic diversity to boost yeast’s industrial v...
2019-01-16 | MTBLS780 | MetaboLights
MetabolomicsExploring the interactions between polyphenols in the fermented grains of sauce-flavor Baijiu and Saccharomyces cerevisiae based on transcriptomic and metabolomic approaches
Polyphenols are abundant in the raw materials (sorghum and wheat) used for sauce-flavor Baijiu fermentation, yet their interactions with the key brewing microorganism (Saccharomyces cerevisiae), remain poorly characterized. This study employed integrated transcriptomic and metabolomic approaches to ...
2026-06-29 | MTBLS14885 | MetaboLights
MetabolomicsLipidCreator workbench to probe the lipidomic landscape - Targeted lipidomics analysis of S. cerevisiae to determine true and false identification

Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope...

2020-04-15 | MTBLS1376 | MetaboLights
MetabolomicsUnveiling superior phenol detoxification and degradation ability in Candida tropicalis SHC-03: A comparative study with Saccharomyces cerevisiae BY4742

This study examined the phenol degradation capabilities and oxidative stress responses of Candida tropicalis SHC-03, demonstrating its metabolic superiority and resilience compared to Saccharomyces cerevisiae BY4742 in a culture medium with phenol as the sole carbon source. Through comparative gr...

2024-10-04 | MTBLS10757 | MetaboLights
MetabolomicsSingle-cell and bulk level metabolomic study of the glycolysis inhibition by 2-deoxy-D-glucose in Saccharomyces cerevisiae
Single-cell level measurements are necessary to characterize the intrinsic biological variability in a population of cells. In a study of the metabolic response of a clonal Saccharomyces cerevisiae population challenged by the glycolytic inhibitor 2-deoxy-D-glucose (2-DG), this variability is shown ...
2013-05-22 | MTBLS29 | MetaboLights
MetabolomicsLipidomic and Metabolomic Changes in Commercial Brewing Strains of Saccharomyces cerevisiae to QSM 2-Phenylethanol

Commercially relevant Saccharomyces cerevisiae strains were cultivated under nitrogen-limiting (SLAD) and nitrogen-sufficient (SHAD) conditions, some supplemented with 200 μM of the aromatic alcohol 2-phenylethanol. After incubation at 24 °C for 72 h, cells were harvested from each condition and ...

2025-03-14 | MTBLS11283 | MetaboLights
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