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ProteomicsThe mechanism to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes
Endoplasmic reticulum (ER)-associated degradation (ERAD) and ER-phagy are two principal degradative mechanisms in the ER; however, the crosstalk between these two pathways and its physiological significance remain unexplored. Here we report that SEL1L-HRD1 ERAD limits autophagy and that, when ERAD i...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-25 | PXD040899 | Pride
Autophagy Lipoprotein lipase Tryptophan loop Sel1l-hrd1 erad Cerfs Bip Er-phagy Protein aggregation Phase separation Soluble-to-insoluble phase transition 
UnknownThe mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes.
Not available
S-EPMC10229581 | biostudies-literature
ProteomicsCoalescence of endoplasmic reticulum fragments form a new quality-control compartment in adipocytes
Using a combination of state-of-the-art (ultra-) imaging, biochemical and biophysical techniques, this study not only uncover a new cellular quality-control compartment, but demonstrate a profound cellular adaptation capability and plasticity in dealing with misfolded proteins or protein aggregates ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-25 | PXD038310 | Pride
Autophagy Lipoprotein lipase Tryptophan loop Sel1l-hrd1 erad Cerfs Bip Er-phagy Protein aggregation Phase separation Soluble-to-insoluble phase transition 
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