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ProteomicsNpr2-mediated cGMP signalling modulates S-palmitoylation and controls growth cone morphology of DRG neurons
A cGMP signalling cascade composed of the ligand C-type natriuretic peptide (CNP), the natriuretic peptide receptor 2 (Npr2) and the cGMP-dependent kinase Iα (cGKI) is implicated by growth cone splitting in the bifurcation of afferents from dorsal root ganglia (DRG), cranial sensory ganglia (CSG) an...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010326 | Pride
Ap-ms Cgmp signalling Shotgun 
TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
GenomicsChIP-Seq of the Sinorhizobium meliloti CRP-like protein Clr in combination with either cAMP or cGMP under different growth conditions
In bacteria, Crp-Fnr superfamily transcription factors mediate 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) signaling. The CRP-like protein Clr of the soil-dwelling and plant-symbiotic α-proteobacterium Sinorhizobium meliloti was previously shown to act...
ORGANISM(S): Sinorhizobium meliloti 
2023-03-23 | E-MTAB-11788 | biostudies-arrayexpress
GenomicsThe phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-mediated control of Notch signaling
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-mediated control of Notch signaling
PRJEB57972 | ENA
ProteomicsProteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies.
Nitric oxide (NO) is an important signaling molecule in the cardiovascular system. Reduced bioavailability of NO results in debilitated signaling, which contributes to the pathogenesis of cardiometabolic disorders. However, the alterations in signaling under NO deficiency remain mostly unknown. T...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-29 | PXD060084 | Pride
Heart Cgmp signaling Cardiometabolic disorders Nitric oxide 
ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared to wild-type P. b...
ORGANISM(S): Plasmodium berghei 
2025-06-03 | PXD063225 | Pride
Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite plasmodium berghei 
ProteomicsLoss of Serine/Threonine Protein Phosphatase 6 Severely Impairs Sexual Stage Development in Malaria Parasite Plasmodium berghei
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which was associated with the plasma membrane of macrogametes and ookinetes. Compared to wild-type P. b...
ORGANISM(S): Plasmodium berghei 
2025-06-27 | PXD063164 | Pride
Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite plasmodium berghei 
OtherHuntingtin associated protein (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP), specific for the cGMP-dependent protein kinase Iβ isoform.
Data from ProteomeXchange, PXD ID: PXD001434. Published as part of J Biol Chem. 2015 Feb 4. pii . From the Abstract: {{i}} ... Here, we extend on this cAMP-based chemical proteomics approach, employing competitive concentrations of free cyclic nucleotides to isolate each kinase and its secondary in...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320007631 | GPMDB
Resource Reanalysis 
UnknowncGMP Signaling, Phosphodiesterases and Major Depressive Disorder.
Not available
S-EPMC3263465 | biostudies-literature
GenomicsNaringenin modulates the NO-cGMP-PKG signaling pathway through AKT binding to enhance osteogenic differentiation in hPDLSCs
Naringenin modulates the NO-cGMP-PKG signaling pathway through AKT binding to enhance osteogenic differentiation in hPDLSCs
PRJNA1105999 | ENA
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