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TranscriptomicsTranscription profiling of four mouse bone marrow hematopoietic stem cells (HSC) early B lineage stages(MLP, CLP, Fr.A, Fr.B) to identify coordinately regulated gene as cells progress down the B cell development pathway
Differentiation from hematopoietic stem cells (HSC) to early B-lineage cells proceeds through a series of intermediate stages, during which cells are thought to become progressively more restricted in their developmental potential. RNAs were prepared from four early B lineage stages(MLP, CLP, Fr.A, ...
ORGANISM(S): Mus musculus 
2006-12-16 | E-MEXP-559 | biostudies-arrayexpress
ProteomicsCyclophilin B function elucidated by electrochemical sensors
We have investigated the function of CypB through negative ionization high resolution LCMS and examined the purity of a CypB protein with intact mass analyzes on a Q Exactive mass spectrometer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-19 | MSV000089498 | MassIVE
UnknownMenu labeling, calories, and nutrient density: Evidence from chain restaurants.
Not available
S-EPMC7205205 | biostudies-literature
MetabolomicsTargeted plasma metabolomics combined with machine learning for the diagnosis of acute SARS-CoV-2

The routine clinical diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely restricted to real-time reverse transcription polymerase chain reaction (RT-qPCR), and tests that detect SARS-CoV-2 nucleocapsid antigen. Given the diagnostic delay and suboptimal sensitivity...

2024-08-26 | MTBLS6739 | MetaboLights
TranscriptomicsCardiac Gene Expression Profiling in CryAB R120G Transgenic Mice
Protein aggregation cardiomyopathy is a life-threatening manifestation of a multisystem disorder caused by the exchange mutation in the gene encoding the human small HSP ?B-crystallin (hR120GCryAB). Genetic studies in mice have established cardiac hR120GCryAB expression causes increased activity of...
ORGANISM(S): Mus musculus 
2008-12-12 | E-GEOD-9924 | biostudies-arrayexpress
TranscriptomicsDual Mechanisms by which MiR-125b Represses IRF4 to Induce Myeloid and B cell Leukemias
The oncomir microRNA-125b (miR-125b) is up-regulated in a variety of human neoplastic blood disorders and constitutive up-regulation of miR-125b in mice can promote myeloid and B cell leukemia. We found that miR-125b promotes myeloid and B cell neoplasm by inducing tumorigenesis in hematopoietic pro...
ORGANISM(S): Mus musculus 
2014-06-27 | E-GEOD-58900 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of DYRK1A-deficient (CKO) pre-B and pre-T cells
Pre-B and pre-T lymphocytes must orchestrate a transition from a highly proliferative state to a quiescent one during development. Cyclin D3 is essential for these cells’ proliferation, but little is known about its post-translational regulation at this stage. Here, we show that the dual specificity...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-67052 | biostudies-arrayexpress
UnknownLoss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptide.
Not available
S-EPMC3048413 | biostudies-literature
ProteomicsProteomic Analysis of Lyme Disease: Global Protein Comparison of Three Strains of Borrelia Burgdorferi
We report the proteomic analysis of the archetype B. burgdorferi B31 strain and two other strains (ND40, and JD-1) having different Borrelia pathotypes using strong cation exchange fractionation of proteolytic peptides followed by high-resolution, reversed phase capillary liquid chromatography coupl...
ORGANISM(S): Borreliella Burgdorferi (ncbitaxon:139) 
2020-05-29 | MSV000085503 | MassIVE
UnknownStructural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens.
Not available
S-EPMC2785609 | biostudies-literature
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