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TranscriptomicsTranscription profiling of mouse model of obesity during high fat feeding
We examined the effects of high-fat diet on feeding behaviour, body weight regulation and common biomarkers associated with weight gain in the C57BL/6J mice over a period of 10 weeks, making measurements at weeks 2, 4 and 10. We examined the transcriptomic profile of hepatic genes involved in the ma...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8753 | biostudies-arrayexpress
TranscriptomicsBile-inducible membrane protein mediates the bile resistance phenotype of Bifidobacterium breve UCC2003
Bbr_0838 from Bifidobacterium breve UCC2003 encodes a 683 residue membrane protein, that contains a permease domain displaying similarity to transporters belonging to the major facilitator superfamily, as well as a CBS (cystathionine beta synthase) domain. The high level of similarity to bile-efflux...
ORGANISM(S): Bifidobacterium breve UCC2003 
2012-02-20 | E-GEOD-31224 | biostudies-arrayexpress
GenomicsChIP-Seq for ERK2/MAPK1 and ELK1 in human embryonic stem cells
The ERK/MAPK signal transduction cascade is one of the key pathways regulating proliferation and differentiation in development and disease. In human embryonic stem cells (hESCs), ERK signaling is required for their self-renewing property. Here we studied the convergence of the ERK signaling cascade...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-MTAB-1565 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of the pancreas samples from animals showing autoimmune pancreatitis and chronic pancreatitis
Autoimmune pancreatitis (AIP) is a disease with unclear immunologic triggers. This study shows that the pancreatic stellate cells are involved in the regulation of the immune response and can cause autoimmunity when the NF-κB signalling in these cells is disrupted.
ORGANISM(S): Mus musculus 
2022-03-31 | E-MTAB-7274 | biostudies-arrayexpress
TranscriptomicsMolecular Classification of AIDS-Related Lymphomas
Gene expression profiling (GEP) of ARL patient samples was done to determine whether gene expression signatures derived from HIV- lymphomas retained their ability to molecularly classify HIV+ lymphomas. The GEP-based predictors robustly classified ARL tumors, distinguishing molecular Burkitt lymphom...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-17189 | biostudies-arrayexpress
GenomicsGenome-wide mapping of PRDM14 binding sites in human embryonic stem cells
PRDM14 belongs to the PR (PRDI-BF1 and RIZ) domain proteins (PRDM) family which is a subclass of the SET domain proteins, a common domain found in histone modifying enzymes. PRDM14 has been previously implicated to regulate self-renewal of hESCs as knock-down of PRDM14 induced expression of differen...
ORGANISM(S): Homo sapiens 
2010-10-20 | E-GEOD-22767 | biostudies-arrayexpress
TranscriptomicsMolecular Classification of AIDS-Related Lymphomas [including third-party data]
Gene expression profiling (GEP) of ARL patient samples was done to determine whether gene expression signatures derived from HIV- lymphomas retained their ability to molecularly classify HIV+ lymphomas. The GEP-based predictors robustly classified ARL tumors, distinguishing molecular Burkitt lymphom...
ORGANISM(S): Homo sapiens 
2012-07-17 | E-GEOD-17372 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analysis of Transcriptional Reprogramming in Mouse Models of Acute Myeloid Leukaemia
Acute leukaemias are commonly caused by mutations that corrupt the transcriptional circuitry of haematopoietic stem/progenitor cells. However, the mechanisms underlying large-scale transcriptional reprogramming remain largely unknown. Here we investigated transcriptional reprogramming at genome-scal...
ORGANISM(S): Mus musculus 
2011-02-17 | E-GEOD-25539 | biostudies-arrayexpress
GenomicsThe histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation
Here we show that T-box proteins team up with chromatin modifying enzymes to drive the expression of the key lineage regulator, Eomes during endodermal differentiation of embryonic stem (ES) cells. The Eomes locus is maintained in a transcriptionally poised configuration in ES cells. During early di...
ORGANISM(S): Mus musculus 
2013-04-18 | E-GEOD-44764 | biostudies-arrayexpress
TranscriptomicsBowel expression profiles of infants with gastrointestinal conditions
We have employed whole genome microarray expression profiling to identify genes differentially expressed in neonatal bowel tissues of different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotising enterocolitis (NEC) and spontaneous i...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-46619 | biostudies-arrayexpress
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