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TranscriptomicsThe histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric glioma cases. The median survival of this group of patients after diagnosis is ∼1 yr. Here we show that the levels of H3...
ORGANISM(S): Homo sapiens 
2014-09-20 | E-GEOD-61586 | biostudies-arrayexpress
ProteomicsPLK1 inhibition induces synthetic lethality in Fanconi anemia pathway-deficient acute myeloid leukemia
Overall survival of acute myeloid leukemia (AML) remains limited. Inhibitors of the master mitotic kinase PLK1 have emerged as promising therapeutics, demonstrating efficacy in an undefined subset of AML patients. However, the clinical success of PLK1 inhibitors remains hindered by a lack of predict...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-09 | MSV000096625 | MassIVE
ProteomicsDefining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between breast cancer subtypes, and provide clinically relevant biological insights towards TNBC. Using CRISPR/Cas9-mediated gene editing, we identify genes that are specifically regulated by TNB...
ORGANISM(S): Homo Sapiens 
2021-03-04 | PXD024505 |
UnknownHuman germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.
Not available
S-EPMC10037107 | biostudies-literature
UnknownDurvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial.
Not available
S-EPMC10824389 | biostudies-literature
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