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TranscriptomicsTranscriptomic and phenotypic variation for salt stress response in Arabidopsis
Transcriptional variation, also called expression level polymorphism (ELP), contributes to intra-specific phenotypic variation in many organisms. Differentially expressed transcripts are typically enriched for stress-related genes, suggesting that differences in response to the environment are a par...
ORGANISM(S): Arabidopsis thaliana 
2011-08-15 | E-GEOD-16765 | biostudies-arrayexpress
TranscriptomicsComparison of salt stress resistance genes in transgenic Arabidopsis thaliana indicates that extent of transcriptomic change may not predict secondary phenotypic or fitness effects
Engineered abiotic stress resistance is an important target for increasing agricultural productivity.There are concerns, however, regarding possible ecological impacts of transgenic crops. In contrast to the first wave of transgenic crops, many abiotic stress resistance genes can initiate complex do...
ORGANISM(S): Arabidopsis thaliana 
2011-10-05 | E-GEOD-26983 | biostudies-arrayexpress
UnknownProspective study of bevacizumab plus temozolomide in patients with advanced neuroendocrine tumors.
Not available
S-EPMC4874232 | biostudies-literature
ProteomicsDomain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating its tumor suppressive functions, and by conferring aberrant pro-carcinogenic activities. We report here that mis-sense mutants in the p53 DNA-binding domain (DBD) and the transactivation domain (TAD) unexpectedly activate...
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD031725 | JPOST Repository
TranscriptomicsGrowth responses and global gene expression analysis of transgenic mannitol-producing Arabidopsis thaliana
Mannitol is a sugar alcohol that serves as a compatible solute contributing to exceptional salt tolerance in several plant species. Arabidopsis plants transformed with the mannose-6-phosphate reductase (M6PR) gene from celery were dramatically more salt tolerant. Following treatment with 100mM NaCl,...
ORGANISM(S): Arabidopsis thaliana 
2010-03-07 | E-GEOD-18217 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Cbp deficient LSK cells
The transcriptional coactivator Cbp is critical for hematopoietic stem cell (HSC) development. However, its role in adult HSC and the mechanistic detail of Cbp control of HSC function remains unknown. Using conditional deletion of Cbp in the adult HSC compartment, we demonstrate an altered balance b...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-25268 | biostudies-arrayexpress
GenomicsGenome-wide analysis of the binding pattern of the transcriptional co-activator Cbp.
The transcriptional coactivator Cbp is critical for hematopoietic stem cell (HSC) development. However, its role in adult HSC and the mechanistic detail of Cbp control of HSC function remain unknown. Using conditional deletion of Cbp in the adult HSC compartment, we demonstrate an altered balance be...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-25265 | biostudies-arrayexpress
UnknownMethylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer.
Not available
S-EPMC11265541 | biostudies-literature
UnknownA versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics.
Not available
S-EPMC7707824 | biostudies-literature
TranscriptomicsTranscription profiling of C. elegans daf-19(+) and daf-19(-) mutants
By screening for genes possessing canonical X-box sequences in promoters of three Caenorhabditis species, namely C. elegans, C. briggsae and C. remanei, we identified 93 genes (including known X-box regulated genes) that encode putative components of ciliated neurons in C. elegans and are subject to...
ORGANISM(S): Caenorhabditis elegans 
2008-06-14 | E-GEOD-6563 | biostudies-arrayexpress
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