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TranscriptomicsExpression data from RCAS PDGFB/Nestin tv-A glioma cells within Ptprd+/+p16-/- (n=2), Ptprd+/-p16-/- (n=2), and Ptrpd-/-p16-/- (n=3) mice.
PTPRD is a tumor suppressor of glioma that is frequently co-deleted with CDKN2A/p16. We show that Ptprd and p16 cooperate to promote gliomagenesis in the RCAS PDGFB / Nestin tv-A glioma mouse model. We found unique gene expression changes within tumor cells of Ptprd+/-p16-/- vs. Ptprd+/+p16-/- and P...
ORGANISM(S): Mus musculus 
2014-06-02 | E-GEOD-55061 | biostudies-arrayexpress
TranscriptomicsBreast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis
Cancer-specific changes in DNA methylation can alter genetic stability, genomic structure, and gene expression. Promoter CpG island methylation can result in transcriptional silencing and plays an important role in the oncogenic process. We used genome-wide analysis to characterize the methylomes o...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-26349 | biostudies-arrayexpress
TranscriptomicsAgilent 244K aCGH data for colon cancer samples
Mutation of the gene PARK2 is the most common cause of early-onset Parkinson's Disease (PD)1,2. PARK2 encodes a gene product with E3 ubiquitin ligase activity3. In a search for multisite tumor suppressors, we identified PARK2 as a frequently targeted gene on chromosome 6q25.2-q27 in cancer. Here,...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-18638 | biostudies-arrayexpress
UnknownMulticenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.
Not available
S-EPMC5993168 | biostudies-literature
TranscriptomicsConvergence of Mutation and Epigenetic Alterations Identifies Common Target Genes in Breast and Colon Cancer
The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressors have been slowly identified using techniques su...
ORGANISM(S): Homo sapiens 
2009-09-23 | E-GEOD-10613 | biostudies-arrayexpress
GenomicsIntegrated genomic characterization of IDH1 mutant Glioma malignant progression
Gliomas represent approximately 30% of all central nervous system tumors, and 80% of malignant brain tumors. To understand the molecular mechanisms underlying the malignant progression of low-grade Isocitrate Dehydrogenase 1 (IDH1) mutant gliomas, we studied paired tumor samples from 41 patients, co...
EGAS00001001588 | EGA
Genomicsena-DATASET-Yale-19-01-2016-18:21:27:507-133 - samples
Exome sequencing VCF files describing mutations during glioma progression.
EGAD00001001887 | EGA
GenomicsDNA_methylation
DNA methylation microarray
EGAD00010000870 | EGA
GenomicsRna_expression
RNA expression microarray
EGAD00010000869 | EGA
GenomicsYale
Data Access Committee EGAC00001000406
EGAC00001000406 | EGA
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