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ProteomicsTemporal and sex-linked protein expression dynamics in a familial model of Alzheimer’s Disease
Mouse models of Alzheimer’s Disease (AD), which show progression through various AD stages reflective of human pathology, like 5XFAD, are well established tools for uncovering novel AD related pathways. In addition, they permit temporal examination of the intermingling of AD related pathways and can...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-16 | PXD030161 | Pride
Hippocampus Alzheimer’s disease Brain Neurodegenerative diseases Temporal Mice 5xfad 
ProteomicsPhosphoproteomics Profiling of Non-Small Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator
Activation of protein phosphatase 2A (PP2A) is a promising anti-cancer therapeutic strategy given this tumor suppressor’s ability to coordinately downregulate multiple pathways involved with growth and proliferation.Here, we studied the global signaling response signature of a novel small molecule a...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD005698 | Pride
Non-small cell lung cancer Phosphatase activation Signaling response signatures Functional network analysis Label-free phosphoproteomics 
UnknownRich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network.
Not available
S-EPMC4504816 | biostudies-literature
TranscriptomicsComparison of the in vivo transcriptome of the myometrium to the transcriptome of myometrial explants, primary cultured myometrial cells and the hTert myometrial cell line
Circulating progesterone (P4) levels decline before the onset of parturition in most animals, but not in humans. This has led to the suggestion that there is functional withdrawal of P4 action at the myometrial level prior to labor onset. Mifepristone is widely used to induce human labour In this st...
ORGANISM(S): Homo sapiens 
2016-05-30 | E-GEOD-77830 | biostudies-arrayexpress
UnknownGlobal Burden of Cardiovascular Diseases and Risks, 1990-2022.
Not available
S-EPMC7615984 | biostudies-literature
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