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TranscriptomicsIdentification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.
Microarray analysis has been useful for identifying the targets of many transcription factors. However, gene expression changes in response to transcription factor perturbation reveal both direct transcriptional targets and secondary gene regulation. By integrating RNA interference, gene expression ...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15440 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of cell cycle transcripts by p53-inducible microRNAs, miR -192 and -215
Cell cycle arrest in response to DNA damage is an important anti-tumorigenic mechanism. microRNAs (miRNAs) were shown recently to play key regulatory roles in cell cycle progression. For example, miR-34a is induced in response to p53 activation and mediates G1 arrest by down-regulating multiple ce...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13105 | biostudies-arrayexpress
TranscriptomicsId2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We ...
ORGANISM(S): Mus musculus 
2014-06-29 | E-GEOD-57682 | biostudies-arrayexpress
TranscriptomicsEffect of anti-miR-33 treatment on gene expression in mouse macrophages from atherosclerotic plaques.
Inhibition of miR-33 results in increased cholesterol efflux and HDL-cholesterol levels in mice. In this study we examined the effect of miR-33 inhibition in a mouse model of atherosclerosis and observed significant reduction in atherosclerotic plaque size. At the end of the study, gene expression i...
ORGANISM(S): Mus musculus 
2011-05-20 | E-GEOD-28783 | biostudies-arrayexpress
ProteomicsCell survival and adaptation to chronic endoplasmic reticulum stress in thyrocytes
The large secretory glycoprotein, thyroglobulin, is the primary translation product of thyroid follicular cells. This difficult-to-fold protein is readily susceptible to structural alterations that render the misfolded thyroglobulin unable to be exported from the endoplasmic reticulum (ER) a known c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-25 | MSV000085006 | MassIVE
UnknownAntibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7.
Not available
S-EPMC7852271 | biostudies-literature
UnknownIncreased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization.
Not available
S-EPMC7852232 | biostudies-literature
UnknownRandomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final results.
Not available
S-EPMC4820756 | biostudies-literature
GenomicsBrg1 activates enhancer repertoires to establish B cell identity and modulate cell growth
Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros. However, how the genome-wide binding patterns of these regulators are modulated during B-lineage development remains to be determined. Here, we found that in lymphoid pr...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-66978 | biostudies-arrayexpress
UnknownStructure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes.
Not available
S-EPMC7315997 | biostudies-literature
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