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ProteomicsEngineering Corynebacterium glutamicum to produce the biogasoline isopentenol from plant biomass hydrolysates
Background. Many microbial hosts used for the rapid discovery and development of metabolic pathways can have sensitivities to final products and process reagents. Isopentenol, a biogasoline candidate, has an established heterologous gene pathway but is toxic to many microbial hosts. Reagents used in...
ORGANISM(S): Corynebacterium Glutamicum Atcc 13032 
PXD012293 | panorama
UnknownAssociation of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis.
Not available
S-EPMC3121053 | biostudies-literature
TranscriptomicsThe effect of cortex/medulla proportions on molecular diagnoses in kidney transplant biopsies: rejection and injury can be assessed in medulla
Histologic assessment of kidney transplant biopsies relies on cortex rather than medulla, but for microarray studies, the proportion cortex in a biopsy is typically unknown and could affect the molecular readings. The present study aimed to develop a molecular estimate of proportion cortex in biopsi...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-GEOD-95611 | biostudies-arrayexpress
GenomicsDirect roles of SPEECHLESS in the specification of stomatal self-renewing cells [ChIP-Seq]
Lineage-specific stem cells are critical for the production and maintenance of specific cell types and tissues in multicellular organisms. In higher plants, the initiation and proliferation of stomatal stem cells is controlled by the basic helix-loop-helix transcription factor SPEECHLESS (SPCH). The...
ORGANISM(S): Arabidopsis thaliana 
2014-09-04 | E-GEOD-57497 | biostudies-arrayexpress
TranscriptomicsA transcriptional map following the developmental trajectory of the Arabidopsis stomatal lineage
Developmental transitions can be described in terms of morphology and individual genes expression patterns, but also in terms of global transcriptional and epigenetic changes. Most of the large-scale studies of such transitions, however, have only been possible in synchronized cell culture systems. ...
ORGANISM(S): Arabidopsis thaliana 
2015-04-06 | E-GEOD-58856 | biostudies-arrayexpress
TranscriptomicsA transcriptional map following the developmental trajectory of the Arabidopsis stomatal lineage
Developmental transitions can be described in terms of morphology and individual genes expression patterns, but also in terms of global transcriptional and epigenetic changes. Most of the large-scale studies of such transitions, however, have only been possible in synchronized cell culture systems. ...
ORGANISM(S): Arabidopsis thaliana 
2015-04-06 | E-GEOD-58855 | biostudies-arrayexpress
TranscriptomicsDirect roles of SPEECHLESS in the specification of stomatal self-renewing cells [RNA-seq]
Lineage-specific stem cells are critical for the production and maintenance of specific cell types and tissues in multicellular organisms. In higher plants, the initiation and proliferation of stomatal stem cells is controlled by the basic helix-loop-helix transcription factor SPEECHLESS (SPCH). The...
ORGANISM(S): Arabidopsis thaliana 
2014-09-04 | E-GEOD-57953 | biostudies-arrayexpress
TranscriptomicsMolecular diagnosis of T cell and/or antibody-mediated rejection in human kidney transplant biopsies
Histologic diagnosis of T cell-mediated rejection in kidney transplant biopsies has limited reproducibility because it is based on non-specific lesions using arbitrary rules that are subject to differing interpretations. We used microarray results from 403 indication biopsies previously given histol...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-36059 | biostudies-arrayexpress
TranscriptomicsA gp130-induced Src/Yes-YAP Cascade Links Inflammation to Regeneration in the Mammalian Intestine
gp130Act cDNA was PCR-amplified and inserted into a plasmid containing the 12.4-kb Villin promoter. The 15.7-kb expression cassette was excised by PmeI digestion, purified, and injected into fertilized C57BL/6 oocytes to obtain founder mice, two of which transmitted the gp130Act transgene. Small int...
ORGANISM(S): Mus musculus 
2015-02-21 | E-MTAB-2400 | biostudies-arrayexpress
TranscriptomicsAssessing rejection-related disease in kidney transplant biopsies based on archetypal analysis of molecular phenotypes
Molecular phenotyping of biopsies affords opportunities for increased precision and improved disease classification to address the limitations of conventional histologic diagnostic systems. We applied archetypal analysis, an unsupervised method similar to cluster analysis, to microarray data from 12...
ORGANISM(S): Homo sapiens 
2017-07-10 | E-GEOD-98320 | biostudies-arrayexpress
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