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TranscriptomicsGene expression profiling of xenografts and mouse embryonic fibroblasts with ectopically expressed PREX2 mutants
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-57311 | biostudies-arrayexpress
TranscriptomicsExpression data from melanoma xenograft tumors originating from primary immortalized melanocytes
PREX2 truncating mutations occur in melanoma. We used microarray based gene expression profiling to compare expression patterns between xenografts harboring control GFP, wt PREX2 or various human relevant PREX2 mutants Primary xenograft tumors derived from primary immortalized melanocytes expressing...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-57309 | biostudies-arrayexpress
TranscriptomicsExpression data from Suv420h1 knockout and mutant PREX2 expressing MEFs (mouse embryonic fibroblasts)
PREX2 truncating mutations occur in melanoma. We used microarray based gene expression profiling to compare expression patterns between cells harboring Suv420h1 knockout and PREX2 mutant expressing Spontaneously immortalized MEFs from either wt or Suv420h1 knockout mice were used. Wt MEFs were trans...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-57310 | biostudies-arrayexpress
TranscriptomicsPro-invasion metastasis drivers in early stage melanoma are oncogenes
Clinical and genomic evidence support the view that the metastatic potential of a primary tumor may be dictated by transforming events acquired early in the tumorigenic process. It has been proposed that the presence of such pro-metastatic events in early-stage tumors reflects their additional capa...
ORGANISM(S): Mus musculus 
2011-07-11 | E-GEOD-29074 | biostudies-arrayexpress
TranscriptomicsCystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF). However, understanding its pathogenesis has been hindered by lack of an animal model with characteristic features of CF. To overcome this problem, we recently generated pigs with targeted CFTR genes. We now report that ...
ORGANISM(S): Sus scrofa 
2010-09-17 | E-GEOD-21071 | biostudies-arrayexpress
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