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GenomicsThe Genomic Binding Sites of an Endogenous Non-Coding RNA
Long non-coding RNAs (lncRNAs) have important regulatory roles and can function at the level of chromatin. To determine where lncRNAs bind to chromatin, we developed CHART, a hybridization-based technique that specifically enriches endogenous RNAs along with their targets from reversibly-crosslinked...
ORGANISM(S): Drosophila melanogaster 
2011-12-07 | E-GEOD-28180 | biostudies-arrayexpress
TranscriptomicsNCIC CTG MA.22 phase I/II trial of epirubicin and docetaxel in locally advanced breast cancer on 2-weekly or 3-weekly schedules
This phase I/II neoadjuvant trial determined maximally-tolerated doses (MTD), dose-limiting toxicities (DLT), response-to-therapy, and explored the role of new response biomarkers. The combination regimens were delivered with acceptable toxicity, good clinical response, inducing changes in tumor RNA...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-GEOD-66999 | biostudies-arrayexpress
ProteomicsDLG2 knockout reveals neurogenic transcriptional programs underlying neuropsychiatric disorders and cognition
A complex train of events unfolds during brain development, guided by activation/repression of gene expression programs. It remains unclear how this process is disrupted in disease. Here we integrate human genetics with transcriptomic data from differentiation of human embryonic stem cells into cort...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD029526 | Pride
Human Dlg2 Neurons Lc-ms/ms 
UnknownPest-removal services provided by birds on subsistence farms in south-eastern Nigeria.
Not available
S-EPMC8351970 | biostudies-literature
TranscriptomicsMIRNA Gene Evolution in Arabidopsis lyrata and Arabidopsis thaliana: Illumina sequencing
Deep sequencing of small RNA from three closely related brassicaceae A. thaliana, A. lyrata and Capsella rubella was done to systematically analyze the evolution of MIRNA genes and their targets. Small RNA were extracted from total RNA by size fractionation and converted to DNA amplicons by serial a...
ORGANISM(S): Arabidopsis lyrata 
2010-05-14 | E-GEOD-20660 | biostudies-arrayexpress
UnknownA megastudy of text-based nudges encouraging patients to get vaccinated at an upcoming doctor's appointment.
Not available
S-EPMC8157982 | biostudies-literature
UnknownNfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells.
Not available
S-EPMC9365269 | biostudies-literature
TranscriptomicsExpression analysis of picloram responsive genes preceding cell elongation in Arabidopsis hypocotyls.
In this study we profile expression of target genes downstream of auxin signaling in Arabidopsis hypocotyls elongating in response to auxin. The synthetic auxin picloram is used in order to take advantage of the picloram-resistant auxin receptor mutant afb5-5, which fails to elongate in response to ...
ORGANISM(S): Arabidopsis thaliana 
2012-04-12 | E-GEOD-37217 | biostudies-arrayexpress
UnknownAltered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis.
Not available
S-EPMC12276992 | biostudies-literature
UnknownA Randomized Trial of Behavioral Nudges Delivered Through Text Messages to Increase Influenza Vaccination Among Patients With an Upcoming Primary Care Visit.
Not available
S-EPMC10798571 | biostudies-literature
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