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ProteomicsProtease specificity profiling in a pipette tip using “charge-synchronized” proteome-derived peptide libraries
About 2% of the genome of human and other organisms codes for proteases. An important step toward deciphering the biological function of a protease and designing inhibitors is the profiling of protease specificity. In this work we present a novel, label-free, proteomics-based protease specificity pr...
ORGANISM(S): Escherichia coli 
2018-04-26 | PXD007556 | Pride
Charged-synchronized peptide library Protease specificity Chafratip Label-free 
ProteomicsDistinct Impact of Neuronal and Astrocytic IFNAR1 Loss in Parkinson-like Dementia
Interferon-alpha/beta-receptor (IFNAR) signal defects were recently identified to contribute to sporadic Parkinson’s disease (PD) with dementia (PDD). Mice lacking interferon-beta (IFNβ) develop PDD-like disease; however, the phenotypic, cellular, and molecular impacts of IFNAR1 loss in vivo have no...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD037113 | Pride
Ifnar1 Glutamatergic neurotransmission Snrna-seq Parkinson’s disease dementia Lc-ms/ms 
ProteomicsDeep Visual Proteomics defines single-cell identity and heterogeneity
Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance measurements. Here we introduce Deep Visual Proteomics (DVP), which combines artificial-intelligence-driven ima...
ORGANISM(S): Homo sapiens (Human) 
2022-04-27 | PXD023904 | Pride
Microscopy Digital pathology Proteomics Laser microdissection 
ProteomicsLaser capture proteomics reveals new candidates for sperm-interacting proteins in the bovine oviduct epithelium
The proximal region of the oviduct (isthmus) serves as a sperm reservoir in many mammalian species. This reservoir is composed of epithelial cells that bind sperm primarily to their apical cilia and ensure the survival of high-quality sperm until ovulation. The species-specific molecular interaction...
ORGANISM(S): Bos taurus (Bovine) 
2025-07-28 | PXD055890 | Pride
Proteomics Oviduct epithelium Dia Cell bodies Data independant analysis Apical part Laser microdissection 
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