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TranscriptomicsTranscription profiling of human HeLa cells in response to IKAP/hELP1 siRNA transfection and/or tumor necrosis factor-a treatment
HeLa cells were un-transfected or transfected with specific siRNAs (20µM) targeting IKAP/hELP1 or non-specific siRNAs against GFP. Same experiment was done by stimulating the cells for 1 hour with TNF-a (200U/ml). conditions: 1/untransfected 2/siRNAs IKAP 3/untransfected + TNF-a 200U/ml 1h 4/siRNAs ...
ORGANISM(S): Homo sapiens 
2022-11-21 | E-MEXP-641 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Cystic Fibrosis cell line and a control cell line
comparison of expression profiles between a cystic fibrosis cell line and a control cell line
ORGANISM(S): Homo sapiens 
2007-09-26 | E-MEXP-980 | biostudies-arrayexpress
ProteomicsLoss of the lipid transfer protein STARD7 triggers metabolic reprogramming and an epigenetic-mediated cell cycle arrest in breast cancer
Cancer cells have to constantly adapt their metabolism to support aberrant cell proliferation. However, the functional link between metabolic reprogramming and cell cycle progression remain largely unexplored. Mitochondria rely on the transfer of multiple lipids from the endoplasmic reticulum (ER) t...
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD046984 | Pride
Metabolism Lipid transfer Cancer 
ProteomicsQuantitative proteomics analysis of Elp3 deficient bone marrow derived macrophages aggragates with or without IL-4 treatment
Alternative macrophages are critical in parasites defense, the resolution of inflammation and wound healing. RNA modifications, which are defined as post-transcriptional changes in the chemical composition of RNA molecules, are involved in the immune response.Among tRNA-modifying enzymes which targe...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-12 | PXD023588 | Pride
Aggregates Mouse bone marrow derived macrophages 
ProteomicsThe proteomic of IL-4 treated BMDMs from Wt and Elp3 KO mice
This experiement aims to know what the differences of protein translation are in the bone marrow derived macro-phages(BMDMs) from WT mice and Elp3 KO mice. We treated the BMDMs with or without IL-4 for 4 hours.
ORGANISM(S): Mus musculus (Mouse) 
2022-09-12 | PXD033962 | Pride
M2 macrophages  il-4  elp3 
ProteomicsEffects of mitochondrial stress on intestinal tumor development depends on Apc status
Mitochondrial stress triggers both metabolic and transcriptomic reprogramming but its effects on tumor development remains unclear. It is also unknown whether the genetic status has any influence on the capacity of mitochondrial stress to control tumor development. To explore these issues, we genera...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-19 | PXD046922 | Pride
Metabolism Colon cancer 
ProteomicsThe lipid transfer protein STARD7 controls intestinal tumor development in a contextdependent manner
lipid extracts were then individually transferred to new vials and separated on a Dionex UltiMate 3000 LC System (Thermo Scientific, Waltham, Massachusetts, EUA) using a Kinetex C18 EVO 2.6uM, 100A, 150 x 0.3 mm LC Column. Mobile phases consist of (A) H2O - 5mM ammonium formate, 0.1% Formic acid, (B...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2026-02-23 | MSV000100938 | MassIVE
TranscriptomicsExpression data from BCL-3 overexpression HaCat cells
Constitutive activation of EGFR- and NF-kB-dependent pathways is a hallmark of cancer, yet signaling proteins that connect both oncogenic cascades are poorly characterized. Here we define KIAA1199 as a BCL-3- and p65-dependent gene in transformed keratinocytes. KIAA1199 expression is enhanced upon h...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-60551 | biostudies-arrayexpress
TranscriptomicsBT549 cells depleted of ELP3 compared to control
Understand the proteome dependent on the mcm5s2 U34 tRNA modification in breast cancer
ORGANISM(S): Homo sapiens 
2020-06-20 | E-MTAB-9206 | biostudies-arrayexpress
UnknownThe lipid transfer protein STARD7 controls intestinal tumor development in a context-dependent manner
Not available
S-SCDT-10_1038-S44321-026-00409-5 | biostudies-other
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