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ProteomicsAnalysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosis
the aim of the project is to characterise circulating protein aggregates and evaluate their protein composition in order to define new biomarkers of neurodegeneration in blood
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD018938 | Pride
Brain Plasma Aggregates Neurodegeneration 
Genomicsmethanogenic aggregates
methanogenic aggregates Metagenome
PRJNA392828 | ENA
ModelsMasel2000 - Drugs to stop prion aggregates and other amyloids
Masel2000 - Drugs to stop prion aggregates and other amyloids Encoded non-curated model. Issues:  - Missing initial concentration for species y, yb and z - Not reproducible figures This model is described in the article: Designing drugs to stop the formation of prion aggregates an...
2015-04-15 | MODEL1410310000 | BioModels
ProteomicsGeneration of aggregates of alpha-lactalbumin by UV-B light exposure
Whey proteins are widely used as ingredients in the form of aggregates to obtain certain functionalities in food applications. The aim of this study was to understand how UV illumination generates aggregates of alpha-lactalbumin (a-LA) as an alternative to heat treatments traditionally used for indu...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2019-12-16 | MSV000084695 | MassIVE
TranscriptomicsTranscriptome profile in the human synovial MSC-aggregates
One of strategies to regenerate cartilage defect is transplantation of mesenchymal stem cells (MSCs). Improvements of therapeutic potential of MSCs are needed to achieve successful cartilage regeneration by transplantation of a limited number of cells. Aggregated culture is a popular method in ES an...
ORGANISM(S): Homo sapiens 
2012-05-12 | E-GEOD-31980 | biostudies-arrayexpress
GenomicsCyanobacterial Aggregates
Cyanobacterial Aggregates 16S rRNA Sequence
PRJNA429935 | ENA
ProteomicsAging-triggered iron-rich insoluble protein aggregates in the spleen originate chiefly from red pulp macrophages.
Both iron homeostasis and erythropoiesis are known to be affected by aging. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by red pulp macrophages (RPMs) in the spleen. Given that RPMs continuously process iron, their cell...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-02 | PXD038660 | Pride
Iron-rich protein aggregates Iron-dextran injection Mouse Red pulp macrophages Spleen 
GenomicsSoil Aggregates
Soil Aggregates 16S rRNA and ITS Amplicon Sequences
PRJNA794192 | ENA
TranscriptomicsGlobal expression of mouse hepatocytes cultured as monolayers or as three-dimensional aggregates
Three-dimensional (3D) culture of hepatocytes leads to improved and prolonged synthetic and metabolic functions, but the underlying molecular mechanisms were unknown. In order to investigate the molecular mechanisms underlying 3D cell-cell interactions in maintaining hepatocyte differentiated funct...
ORGANISM(S): Mus musculus 
2013-12-23 | E-GEOD-53054 | biostudies-arrayexpress
ProteomicsProtein composition of TGFBI-R124C and TGFBI-R555W associated aggregates suggests multiple mechanisms leading to Lattice and Granular corneal dystrophy
Transforming Growth Factor Beta-induced (TGFBI)-related dystrophies constitute the most common heritable forms of corneal dystrophy worldwide. However, other than the underlying genotypes of these conditions, a limited knowledge exists of the exact pathomechanisms of these disorders. This study expa...
ORGANISM(S): Homo sapiens (Human) 
2015-11-18 | PXD002236 | Pride
Granular corneal dystrophy Lattice corneal dystrophy Human cornea 
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