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TranscriptomicsWidespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
Transfected siRNAs and miRNAs regulate numerous transcripts that have only limited complementarity to the active strand of the RNA duplex. This process reflects natural target regulation by miRNAs, but is an unintended (â??off-targetâ??) consequence of siRNA-mediated silencing. Here we demonstrate...
ORGANISM(S): Homo sapiens 
2006-09-12 | E-GEOD-5814 | biostudies-arrayexpress
TranscriptomicsIdentification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.
Microarray analysis has been useful for identifying the targets of many transcription factors. However, gene expression changes in response to transcription factor perturbation reveal both direct transcriptional targets and secondary gene regulation. By integrating RNA interference, gene expression ...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15440 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of cell cycle transcripts by p53-inducible microRNAs, miR -192 and -215
Cell cycle arrest in response to DNA damage is an important anti-tumorigenic mechanism. microRNAs (miRNAs) were shown recently to play key regulatory roles in cell cycle progression. For example, miR-34a is induced in response to p53 activation and mediates G1 arrest by down-regulating multiple ce...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13105 | biostudies-arrayexpress
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