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ProteomicsB-catenin downregulates Dicer to promote ovarian cancer metastasis
Ovarian cancer is a nearly uniform lethal disease and its highly aggressive metastatic phenotype portends a poor prognosis. Lack of a well-controlled, relevant experimental model has been a major obstacle to identifying key molecules causing metastasis. Here we describe the creation of a new isogeni...
ORGANISM(S): Homo sapiens (Human) 
2017-07-03 | PXD006327 | Pride
Dicer Ovarian cancer Microrna -catenin Metastasis 
ProteomicsAn Anti-Cancer Gold(III)-Activated Porphyrin Scaffold that Covalently Modifies Protein Cysteine Thiols
Cysteine thiols of many cancer-associated proteins are attractive targets of anti-cancer agents. Herein, we unequivocally demonstrate a distinct thiol-targeting property of gold(III) mesoporphyrin IX dimethyl ester (AuMesoIX) and its anti-cancer activities. While the binding of cysteine thiols with ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD016875 | Pride
Gold • porphyrin • ligand reactivity• cysteine thiol conjugation • anti-tumor agents 
ProteomicsShotgun Proteomics and Quantitative Pathway Analysis Study of the Mechanisms of Action of Dehydroeffusol, a Bioactive Phyto-chemical in Medulla Junci with Anti-cancer Activity
Dehydroeffusol (DHE) is a rare compound of phenanthrene class isolated from Medulla Junci used in Traditional Chinese herbal medicines. Initial biological evaluation of this compound reveals in vitro and in vivo anticancer ac-tivities. We performed a shotgun proteomic analysis using Orbitrap liquid ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-05 | PXD009389 | Pride
Signaling pathway analysis Phytoestrogen Shotgun proteomics Tmt-labeling 
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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