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Background: Placental metabolic abnormalities are linked to pregnancy complications such as preeclampsia, gestational diabetes mellitus and fetal growth restriction. However, little is known about how the metabolic processes regulate placental development and trophoblast differentiation. The adip...

2025-06-13 | MTBLS12552 | MetaboLights
The aim of the study was to investigate the influence of chemerin on the transcriptomic profile of porcine in vitro cultured luteal cells collected during the mid-luteal phase of estrous cycle.
ORGANISM(S): Sus scrofa 
ccRCC PDX Chemerin mAb treatment
The role of chemerin in clear cell renal cell carcinoma
Chemerin (CHEM) is a hormone mainly expressed in adipocytes involved in the regulation of energy homeostasis and inflammatory response. CHEM expression has been demonstrated in the structures of the porcine hypothalamic-pituitary-gonadal axis, as well as in the uterus, trophoblasts and conceptuses o...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-04-26 | PXD031795 | Pride
5 different human ccRCC PDX models treated or not with an anti chemerin monoclonal antibody
ORGANISM(S): Homo sapiens 
Effect of chemerin in primary human hepatocytes (PHH) and hepatic stellate cells (HSC)
Chemerin is a leukocyte chemoattractant and an adipokine. Overexpression of chemerin by tumor cells or the host inhibits tumor progression in different mouse models, through a mechanism involving the chemerin receptor CMKLR1 and impairment of endothelial cell/pericyte interactions in neovessels.
ORGANISM(S): Mus musculus 
2019-05-05 | GSE98672 | GEO
Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK/NRF2/SLC7A11 axis
The most common subset of renal carcinoma, clear cell renal cell carcinoma (ccRCC), is characterized by accentuated accumulation of neutral lipids in lipid droplets and adipogenic trans-differentiation. Because obesity is a major risk factor in the development of ccRCC, we investigated the role of t...
ORGANISM(S): Homo sapiens 
2021-08-11 | GSE159716 | GEO
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