Chemical denaturation

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CHEBI ID

CHEBI:33942 (1)
CHEBI:17234 (1)
CHEBI:16015 (1)
CHEBI:78320 (1)

Metabolite Name

[(2S,3R,4S,5S)-3-[(2S,3R,4R,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl] (4aS,6aS,6bR,10S,12aR,14bS)-10-[(2R,3R,4S,5S,6R)-4-hydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate_30.2% (1)
NCGC00025125-21!N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide [IIN-based on: CCMSLIB00000845970] (1)
NCGC00380698-01_C24H30O13_Cyclopenta[c]pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-4a-hydroxy-7-methyl-5-oxo-, 2-(3,4-dihydroxyphenyl)ethyl ester, (1S,4aR,7aR)- (1)
2-[4-[(3S,3aR,6S,6aR)-6-[3-methoxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol (1)
(G)(NAM)-AemA;(3s-4)-(G)(NAM)-AemA (1)
MMV676480 (1)
Flavone base + 3O, 2MeO, O-guaiacylglyceryl-Hex (1)
NCGC00347420-02_C39H65NO12_15-Hydroxyspirosolan-3-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside (1)
NCGC00381337-01_C64H104O30_Pentopyranosyl-(1->4)pentopyranosyl-(1->4)-1-O-[(3beta,5xi,9xi,18xi)-3-{[hexopyranosyl-(1->3)hexopyranosyl-(1->4)-6-deoxyhexopyranosyl]oxy}-28-oxoolean-12-en-28-yl]hexopyranose (1)
(7S,9E,11S,12R,13S,14S,15S,16R,17S,18S,19E,21Z)-26-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,2... (1)
NCGC00380818-01_C17H15ClO6_7-Chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohexa[2,5]diene]-3,4'-dione (1)
MGDG (18:3/18:4)_(2S)-1-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(6Z,9Z,12Z,15Z-octa-decatetranoyl)-3-beta-D-galacto-pyranosyl-sn-glycerol (1)
(NAG)(NAM)-AeKA[3-NH2-GGGG] (1)
NCGC00347534-02![2-[4-hydroxy-2,5-bis(hydroxymethyl)-3-(2-methylpropanoyloxy)oxolan-2-yl]oxy-6-(hydroxymethyl)-4,5-bis(2-methylpropanoyloxy)oxan-3-yl] decanoate [IIN-based on: CCMSLIB00000848581] (1)
Methyl 2-(3,5-dichloro-2-hydroxy-6-methoxy-4-methylbenzoyl)-3,5-dihydroxybenzoate (1)
Pesticide3_Chlorfluazuron_C20H9Cl3F5N3O3_Benzamide, N-[[[3,5-dichloro-4-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]amino]carbonyl]-2,6-difluoro- (1)
NCGC00385692-01_C44H68O14_3-Hydroxyspirosta-5,25(27)-dien-1-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-(2-hydroxy-3-methylpentanoyl)-alpha-L-arabinopyranoside (1)
NCGC00384992-01_C20H26O6_ (1)
(NAG)(NAM)-AemAG;(3s-4)-(G)(NAM)-AemA (1)
Solanidine base + O-Hex-Hex (1)
(2S,3R,4S,5R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,6S,8R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol (1)
NCGC00380130-01_C15H26O4_1,2-Naphthalenedimethanol, 1,4,4a,5,6,7,8,8a-octahydro-1,4-dihydroxy-5,5,8a-trimethyl- (1)
NCGC00169037-02_C25H34O8_beta-D-Glucopyranoside, 5-(4-hydroxyphenyl)-1-[2-(4-hydroxyphenyl)ethyl]pentyl (1)
NCGC00347542-02!4-[5-(3,4-dimethoxyphenyl)-3,4-dimethyloxolan-2-yl]phenol [IIN-based on: CCMSLIB00000848919] (1)
Cyclopamine (1)
NCGC00381245-01_C22H30O8_2-[6-{[(2Z)-4-Acetoxy-2-methyl-2-butenoyl]oxy}-2-hydroxy-3-(3-hydroxy-1-propen-2-yl)-4-methyl-4-vinylcyclohexyl]acrylic acid (1)
(2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-((3-(benzo[d][1,3]dioxol-5-yl)-6-ethyl-2-methyl-4-oxo-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (1)
(3?,5?,9?,16?,18?,22?)-22-Acetoxy-16-hydroxy-13,28-epoxyoleanan-3-yl 6-deoxy-?-L-mannopyranosyl-(1->2)-?-D-galactopyranosyl-(1->3)-[?-D-glucopyranosyl-(1->2)]-?-D-glucopyran osiduronic acid_major (1)
NCGC00386015-01_C32H44O8_Estra-1,5-diene-3,11-dione, 17-[(1R,3E)-1-(acetyloxy)-5-hydroxy-1,5-dimethyl-2-oxo-3-hexen-1-yl]-2,16-dihydroxy-4,4,9,14-tetramethyl-, (9beta,10alpha,16alpha,17beta)- (1)
N-ACETYL-D-MANNOSAMINE (1)

First Public Date

2018 (1)

Study type

Transcription profiling by array (212)
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ATAC-seq (1)

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Lab affiliation

Department of Pharmaceutical Chemistry and Bioanalytics Institute of Pharmacy Martin Luther University Halle-Wittenberg Halle (Saale), Germany (3)
Human Technopole, 20157, Milan, Italy (3)
Departments of Chemistry and Biochemistry Duke University (2)
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Biology, Cambridge, MA, USA (2)
.L. Talrose Institute for Energy Problems of Chemical Physics, N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Leninsky Pr. 38, Bld.2, 119334, Moscow, Russia (1)
1. Laboratoire de Spectrométrie de Masse BioOrganique, IPHC UMR 7178, Université de Strasbourg, CNRS, 67000 Strasbourg, France 2. Infrastructure Nationale de Protéomique ProFI – FR2048, 67087 Strasbourg, France (1)
Bio-pharmaceutical Analysis Lab; Department of Pharmaceutical Science; University of Milan; Milan, Italy (1)
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. (1)
Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute (1)
Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85747 Garching b. München (1)
Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching b. München 85747, Germany; Chair of Organic Chemistry II, Technische Universität München, Garching b. München 85747, Germany (1)
Center for Protein Assemblies, Department of Chemistry, Technische Universität München, Ernst-Otto-Fischer-Straße 8, 85747 Garching, Germany (1)
Centre for Advanced Imaging, the University of Queensland (1)
Charite universitymedicine berlin (1)
Chemistry, Fitzgerald, Duke University, USA (1)
Chemistry, Fitzgerald, Duke university, USA (1)
Dalian Institute of Chemical Physics, CAS (1)
Department of Biology, University of Ottawa, Ottawa, Canada, K1N 6N5 (1)
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI USA (1)
Department of Chemical Sciences, University of Catania (1)
Department of Chemistry & Chemical Biology, Northeastern University (1)
Department of Chemistry Washington University in St. Louis (1)
Department of Chemistry and Biochemistry, Georgia Institute of Technology, GA, US (1)
Department of Chemistry and Bioscience Aalborg University Denmark (1)
Department of Chemistry, Duke University (1)
Department of Chemistry, Seoul National University (1)
Department of Environment and Biodiversity, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria (1)
Department of Genome Sciences, University of Washington (1)
Department of Veterinary Biosciences, The University of Melbourne (1)
Departments of Chemistry and Biochemistry, Duke University, United States (1)

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Chemical Denaturation and Protein Precipitation (CPP) on E. coli lysate

Chemical Denaturation and Protein Precipitation (CPP) was performed on an E. coli lysate in order to determine the precipitaiton midpoint for the proteome

ORGANISM(S): Escherichia coli

2023-01-03 | PXD036219 | Pride

Cpp E. coli Precipitation

Analysis of bilirubin-induced bovine serum albumin stability using protein denaturation and quantitative cross-linking mass spectrometry

We report the combination of protein-denaturation stability principles with quantitative cross-linking mass spectrometry using isobaric quantitative protein interaction reporter technologies. This method enables the evaluation of ligand-induced protein engagement through analysis of cross-link rela...

ORGANISM(S): Bos taurus (Bovine)

2024-07-03 | PXD036649 | Pride

Quantitative cross-linking Protein stability Mass spectrometry

Correlation between chemical denaturation and the unfolding energetics of Acanthamoeba actophorin.

Not available

S-EPMC10398266 | biostudies-literature

Single-molecule chemical denaturation of riboswitches.

Not available

S-EPMC3627600 | biostudies-literature

Heat-induced irreversible denaturation of the camelid single domain VHH antibody is governed by chemical modifications.

Not available

S-EPMC4140921 | biostudies-literature