Chemical screen

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Unknown (4284)
Transcriptomics (1327)
Genomics (539)
Proteomics (211)
Metabolomics (106)
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Genomic (4)
Multiomics (4)
Methylation profiling (3)
Clinical (1)

Organisms

Homo sapiens (669)
Mus musculus (328)
Arabidopsis thaliana (87)
Drosophila melanogaster (65)
Danio rerio (60)
Saccharomyces cerevisiae (50)
Rattus norvegicus (33)
Caenorhabditis elegans (23)
Gallus gallus (16)
Medicago truncatula (11)
Schizosaccharomyces pombe (11)
Streptomyces venezuelae (7)
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Oryza sativa (6)
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Zea mays (5)
Escherichia coli (5)
Chlamydomonas reinhardtii (4)
Xenopus laevis (4)
Streptomyces coelicolor A3(2) (4)
Solanum lycopersicum (4)
Trypanosoma brucei (4)
Lemna minor (3)
Agrobacterium tumefaciens (3)
Fundulus heteroclitus (3)
Daphnia magna (3)
Solanum tuberosum (3)
Mycobacterium tuberculosis H37Rv (3)
Staphylococcus aureus (1)
Neisseria gonorrhoeae (1)

Organisms

Homo sapiens (168)
Mus musculus (68)
Danio rerio (13)
Arabidopsis thaliana (11)
Saccharomyces cerevisiae (7)
Xenopus laevis (3)
Caenorhabditis elegans (3)
Brucella ovis (2)
Pseudomonas aeruginosa UCBPP-PA14 (2)
fermentation metagenome (2)
Schizosaccharomyces pombe (2)
Rattus norvegicus (2)
dechlorinating enrichment culture KB-1 (1)
Lactiplantibacillus plantarum WCFS1 (1)
Agrobacterium fabrum str. C58 (1)
Streptococcus pyogenes M49 591 (1)
Trypanosoma brucei brucei (1)
Komagataella phaffii GS115 (1)
Pseudomonas aeruginosa RB (1)
Pinctada radiata (1)
Aspergillus nidulans (1)
Shewanella oneidensis MR-1 (1)
Mesocricetus auratus (1)
Pseudomonas putida (1)
Triticum dicoccoides (1)
Lactuca sativa (1)
Chlorocebus sabaeus (1)
Medicago truncatula (1)
Ambystoma mexicanum (1)
Drosophila melanogaster (1)

Repository

biostudies-arrayexpress (1219)
ENA (397)
geo (277)
pride (105)
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EGA (29)
iProX (23)
jPOST (8)
BioModels (5)
dbGaP (4)
GNPS (4)
PanoramaPublic (4)
PeptideAtlas (4)
GPMDB (2)

Tissue

Cell culture (26)
Epithelial cell (10)
Permanent cell line cell (9)
Kidney cell (7)
Brain (4)
Lung (4)
Bone marrow (3)
Others (2)
Cell suspension culture (2)
Embryo (2)
Embryonic stem cell (2)
Liver (2)
Photosynthetic cell (2)
Blood cell (1)
Cerebrospinal fluid (1)
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Colon (1)
Early embryonic cell (1)
Fungal cell (1)
HEK-293 cell (1)
HeLa cell (1)
Kidney (1)
Leukemia cell (1)
Leukocyte (1)
Lung neuroendocrine cell (1)
Lung squamous cell carcinoma cell (1)
Microglial cell line (1)
Myeloid cell (1)
Pancreas (1)
Plant cell (1)

Disease

Lung cancer (5)
Breast cancer (4)
Prostate cancer (3)
Normal (3)
Not Available (2)
Angelman syndrome (2)
Bone osteosarcoma (2)
Colon cancer (2)
Disease free (2)
Primary acute lymphoblastic leukemia (1)
Pretreatment primary leukemia (1)
MAS (1)
T. circumcincta infection (1)
Cryptozoospermia (1)
"colon adenocarcinoma, acterial infection" (1)
Mock infected (1)
Small cell lung cancer (1)
Infected (1)
Rheumatoid arthritis (1)
IBDV infected (1)
NGT (1)
Mastitis (1)
Chronic lymphocytic leukemia (1)
Chicken Anaemia Virus infected (1)
Cerebral ischemia (1)
Carcinoma (1)
Ovarian cancer (1)
Central nervous system cancer (1)
Neoplasms (1)
Acute leukemia (1)

Technology Type

Mass Spectrometry (105)
Mass spectrometry (70)
Shotgun proteomics (43)
Mass spectrometry assay (29)
Affinity purification coupled with mass spectrometry proteomics (25)
Bottom-up proteomics (20)
Data-dependent acquisition (10)
Chemical cross-linking coupled with mass spectrometry proteomics (9)
Gel-based experiment (9)
Data-independent acquisition (5)
NMR spectroscopy (4)
HDMSE (3)
SWATH MS (2)
Top-down proteomics (2)
Illumina MiSeq, ILLUMINA (1)
Illumina HiSeq 2500, ILLUMINA (1)
Illumina HiSeq 2000, Illumina_2.5M (1)
Illumina HiSeq 2000 (1)
Affinity proteomics (1)
All-ion fragmentation (1)
Mass spectrometry imaging (1)
Proteogenomics (1)
RNA mass spectrometry (1)

Instrument Platform

Illumina HiSeq 2000 (44)
Illumina NovaSeq 6000 (41)
Illumina HiSeq 4000 (40)
Illumina HiSeq 2500 (31)
NextSeq 500 (23)
Illumina MiSeq (9)
Illumina Genome Analyzer IIx (7)
418 [Affymetrix] (5)
ScanArray 5000 [PerkinElmer] (4)
NextSeq 550 (4)
Axon GenePix 4000B scanning hardware (3)
NextSeq 2000 (3)
Gene Titan (2)
454 GS FLX+ (2)
Scanning hardware (2)
Chromium Controller, 10x Genomics and Chromium X, 10x Genomics (1)
Chromium Controller, 10x Genomics and Chromium X, 10x Genomics (1)
Cell culture (1)
Tapestri Platform (1)
Dell PowerEdge R750; CPU: 2 × Intel Xeon Gold 6346 (32 Cores / 64 Threads); RAM: 188 GB (1)
RapidPURE RNA Plant Kit (MP Biomedicals, Illkirch, France) (1)
FastPrep-24 homogeniser (1)
BSL2 Laboratory (1)
MacBook Pro 64Gb RAM; 16-core (1)
Qubit 2.0 Fluorometer; Agilent TapeStation 4200 (1)
Microarray scanner system (1)
Axon-GenePix 4100A (1)
FACSAria (BD) (1)
Illumina Genome Analyzer IIx;Illumina HiSeq 2000 (1)
Agilent Scanner (1)

Publication Date

2010 (175)
2013 (148)
2014 (117)
2012 (114)
2015 (113)
2011 (109)
2025 (108)
2026 (100)
2021 (95)
2008 (90)
2024 (87)
2023 (75)
2016 (71)
2009 (71)
2022 (67)
2020 (53)
2018 (41)
2007 (39)
2019 (36)
2017 (36)
2005 (18)
2006 (15)
2004 (3)
2003 (3)

UNIPROT ID/AC

A0A0A0MR66 (2)
B3KML9 (2)
B4DRV9 (2)
E9PB61 (2)
G5E972 (2)
G8JLB6 (2)
H0YFY6 (2)
H0YJH7 (2)
O00505 (2)
O00566 (2)
O00571 (2)
O14715 (2)
O14950 (2)
O14974 (2)
O14974-4 (2)
O15020 (2)
O15446 (2)
O43290 (2)
O43395 (2)
O60231 (2)
O60568 (2)
O60832 (2)
O60841 (2)
O75151 (2)
O75376 (2)
O75400 (2)
O75400-3 (2)
O75475 (2)
O75475-2 (2)
O75475-3 (2)

ENSEMBL ID

ENSG00000170477 (1)

CHEBI ID

CHEBI:7916 (16)
CHEBI:16704 (16)
CHEBI:30769 (15)
CHEBI:17568 (14)
CHEBI:28044 (13)
CHEBI:16335 (13)
CHEBI:15354 (13)
CHEBI:17351 (13)
CHEBI:18237 (12)
CHEBI:16708 (12)
CHEBI:15891 (12)
CHEBI:30915 (12)
CHEBI:16737 (12)
CHEBI:16347 (12)
CHEBI:15756 (12)
CHEBI:25017 (11)
CHEBI:17268 (11)
CHEBI:18050 (11)
CHEBI:28834 (11)
CHEBI:16919 (11)
CHEBI:17596 (11)
CHEBI:16755 (10)
CHEBI:18186 (10)
CHEBI:17533 (10)
CHEBI:16750 (10)
CHEBI:28842 (10)
CHEBI:15428 (10)
CHEBI:17154 (10)
CHEBI:33282 (1)
CHEBI:50509 (1)

Metabolite Name

Adenosine (20)
Hypoxanthine (19)
Uridine (18)
Pantothenic acid (17)
Creatinine (17)
Uracil (16)
Betaine (16)
Choline (15)
Adenine (15)
Cytidine (15)
Creatine (15)
Deoxycholic acid (14)
Xanthine (14)
Guanosine (14)
L-Phenylalanine (14)
Inosine (14)
L-Proline (13)
Biliverdin (13)
Indole (13)
Methionine (13)
Taurine (13)
Xanthosine (13)
Guanine (13)
Riboflavin (13)
Phosphorylcholine (13)
L-Tryptophan (13)
Azelaic acid (13)
L-Arginine (12)
Citric acid (12)
Spermidine (12)

First Public Date

2026 (57)
2014 (49)
2025 (45)
2023 (43)
2024 (41)
2021 (35)
2020 (29)
2019 (21)
2018 (20)
2022 (19)
2017 (17)
2015 (10)
2016 (6)
2013 (4)
2012 (1)

Modelling Approach

Computational model (3)
Deep learning (1)
Machine learning (1)

Study status

Not provided (1)

Lab affiliation

Principal Investigator Centre for Targeted Protein Degradation, School of Life Sciences (4)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
Department of Genome Sciences, University of Washington, Seattle, WA 98195 USA (2)
Duke University (2)
GSK (2)
Moffitt Cancer Center Tampa, FL (2)
Principal Investigator Centre for Targeted Protein Degradation (2)
Principal Investigator • Centre for Targeted Protein Degradation (2)
1 The Rosalind Franklin Institute, Oxfordshire, United Kingdom 2 Department of Pharmacology, University of Oxford (1)
1)Program for Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), 08916 Badalona, Spain 2)Cancer and Leukemia Epigenetics and Biology Program, Josep Carreras Leukaemia Research Institute (IJC), Campus ICO-GTP-UAB, 08916 Badalona, Spain (1)
1Cancer Institute, the Second Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China 2Cancer Center, Zhejiang University, Hangzhou 310058, China 3Research Center for Life Science and Human Health, Binjiang Institute of Zhejiang University, Hangzhou 310053, China (1)
1Institute of Plant Protection, Agricultural Research Organization, The Volcani Center, Rishon LeZion, Israel (1)
Agios Pharmaceuticals 88 Sidney Street Cambridge MA 02139 USA (1)
Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany Bioanalytics Group, Institute of Clinical Chemistry, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany (1)
Boston College (1)
Cancer Science Institute of Singapore (CSI), National University of Singapore (NUS) (1)
Cancer Science Institute of Singapore, National University of Singapore (1)
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Lazarettgasse 14, AKH BT 25.3 1090 Vienna, Austria (1)
Cell and Chemical Biology LUMC Leiden The Netherlands (1)
Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85747 Garching b. München (1)
Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85747 Garching b. München ( lab head ) (1)
Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching b. München 85747, Germany; Chair of Organic Chemistry II, Technische Universität München, Garching b. München 85747, Germany (1)
Chair of Organic Chemistry II Department of Chemistry Technical University Munich 85748 Garching (1)
Chair of Proteomics and Bioanalytics, Technical University of Munich (1)
Chemical Biology Laboratory, National Cancer Institute (1)
Chemical Proteomics, Division of Physiological Chemistry I, Dept. of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden. (1)
Chemistry Department, The Scripps Research Institute, La Jolla, California, USA (1)
Department of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, 471023, China (1)
Department of Biochemistry and Molecular Biology Graduate School and Faculty of Medicine, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan (1)
Department of Biology University of Konstanz Germany (1)

Keyword

Industry (1)
Genetic (1)
Epidemiology (1)

IsPrivate

False (5)

Submitter Keywords

Ersilia (5)
Machine Learning Model (5)
FAIR-AIML (4)

Classification

bacteria (8)
protozoa (3)
fungi (2)

Study type

Transcription profiling by array (688)
RNA-seq of coding RNA (189)
ChIP-seq (44)
Unknown experiment type (38)
Comparative genomic hybridization by array (38)
RNA-seq of non coding RNA (23)
Other (22)
Proteomic profiling by array (22)
DNA-seq (21)
ChIP-chip by tiling array (20)
Methylation profiling by array (16)
RNA-seq of coding RNA from single cells (12)
Methylation profiling by high throughput sequencing (10)
RNA-seq of total RNA (10)
Cell line - High-throughput sequencing (9)
Animal - High-throughput sequencing (8)
Transcription profiling by tiling array (5)
ChIP-chip by array (5)
MicroRNA profiling by array (5)
High-throughput sequencing (4)
Genotyping by array (4)
Transcription profiling by SAGE (3)
RNAi profiling by array (3)
Transcription profiling by RT-PCR (3)
Plant - High-throughput sequencing (2)
Cell line - One-color microarray (2)
Human - One-color microarray (2)
CLIP-seq (2)
Genotyping by high throughput sequencing (2)
FAIRE-seq (1)

Release Date

2022 (486)
2021 (438)
2023 (412)
2024 (353)
2025 (342)
2019 (324)
2020 (321)
2015 (319)
2018 (286)
2016 (284)
2014 (280)
2013 (259)
2010 (256)
2017 (234)
2012 (221)
2011 (205)
2009 (131)
2008 (131)
2026 (73)
2007 (60)
2005 (28)
2006 (24)
2004 (15)
2003 (12)
2001 (4)
2002 (3)
2000 (1)
1997 (1)

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Assessing the Feasibility of In Vitro Assays in Combination with Biological Matrices to Screen for Endogenous CYP450 Phenotype Biomarkers Using an Untargeted Metabolomics Approach—A Proof of Concept Study

Cytochrome P450 (CYP) enzymes are crucial for drug metabolism, yet inter-individual variability in their activity remains a significant clinical challenge. Current phenotyping methods are often impractical or even impossible, particularly in forensic toxicology and vulnerable populations. This pr...

2025-12-12 | MTBLS13325 | MetaboLights

In vivo screen of Francisella tularensis subsp. novicida mutants in sequence defined transposon library

We used an inhalation mouse model of infection to query a collection of 2149 mutants in a Francisella tularensis subsp. novicida background for genes required for growth, survival and systemic dissemination. A microarray-based genome-wide negative selection screen (Microarray tracking of transposon ...

ORGANISM(S): Francisella tularensis subsp. novicida

2008-12-30 | E-GEOD-11297 | biostudies-arrayexpress

A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer

Through chemical probe screening, we uncovered a novel mechanism of RNA splicing in paclitaxel-resistant TNBC and identified PRMTs as therapeutic targets.

ORGANISM(S): Homo Sapiens

PXD053336 |

Chemical genomic screen identifies SP2509, WT hTERT specific repressor in colorectal cancer

PRJNA838606 | ENA

Oligoarray comparative genomic hybridisation-mediated mapping of suppressors of an essential receptor tyrosine kinase generated in a deletion-biased mutagenesis screen

We have used oligoarray comparative genomic hybridization (aCGH) to identify novel suppressors generated in a UV-TMP based suppressor screen. This approach is suitable for detecting single gene mutations as well as copy number variations. Keywords: C.elegans Suppressor screen array CGH [1] 2 test s...

ORGANISM(S): Caenorhabditis elegans

2012-07-12 | E-GEOD-15224 | biostudies-arrayexpress

Beyond hazard identification: Discovering mechanisms of action from a ToxCast chemical screen in zebrafish

PRJNA1521443 | ENA

An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity, Experiment B

Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-renewal and pluripotency. Here, we present an RNAi screen in mouse ESCs of 1008 loci encoding chromatin proteins. We...

ORGANISM(S): Mus musculus

2008-07-11 | E-GEOD-11241 | biostudies-arrayexpress

An RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation

Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor. The brain-infiltrative character of glioblastoma makes complete surgical removal of the tumor impossible and neither radiation nor current chemotherapy provide cure. Recent evidence shows that glioblastoma mu...

ORGANISM(S): Homo sapiens

2011-03-14 | E-GEOD-27931 | biostudies-arrayexpress

Zebrafish chemical compound screen uncovers inducers of skeletal muscle engraftment across species

PRJNA601746 | ENA

High throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei

During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...

ORGANISM(S): Trypanosoma brucei brucei

2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress

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6514 Results

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