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TranscriptomicsThe 3’UTR of FMR1 mRNA is a target of miR101, miR129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse.
While FMR1 is silenced in Fragile X syndrome (FXS), its expression is elevated (2-8 fold) in premutated individuals. These people may develop the Fragile X-associated Tremor Ataxia Syndrome (FXTAS), a late onset neurodegenerative disorder characterized by ataxia and parkinsonism. In addition, people...
ORGANISM(S): Mus musculus 
2013-03-07 | E-GEOD-43670 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of mouse hippocampal neuronal cultures during development
The expression of components of the synapse proteome was examined in genome-wide transcriptome profiles of differentiating hippocampus neurons (from 0.25 to 16 days in vitro) and microelectrode arrays was used to correlate the gene expression with electrical activity.
ORGANISM(S): Mus musculus 
2007-02-26 | E-MEXP-878 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat control subplate neurons with few synapses and cocultured subplate neurons with induced synaptogenesis
The transcriptional events accompanying synaptogenesis are largely unknown, or have been studied in systems in which synapse formation occurs gradually over time. With a system in which synaptogenesis is synchronized and controllable, molecular or biochemical techniques can be used to examine cellu...
ORGANISM(S): Rattus norvegicus 
2008-11-29 | E-GEOD-8318 | biostudies-arrayexpress
TranscriptomicsMicroarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning
Using Illumina MouseWG-6v2 microarrays, we investigated the gene transcription changes in microglia and peripheral monocytes after contextual fear conditioning of C57BL/6J mice. Mice were trained with or without a single minimized footshock stimulation (0-s or 2-s, 0.4 mA) and re-exposed to the trai...
ORGANISM(S): Mus musculus 
2022-10-28 | E-MTAB-12361 | biostudies-arrayexpress
UnknownNeurobeachin is required postsynaptically for electrical and chemical synapse formation.
Not available
S-EPMC4329981 | biostudies-literature
TranscriptomicsExpression profiles of globular bushy cells (GBCs) during maturation
Calyx of Held giant presynaptic terminals in the medial nucleus of the trapezoid body of the auditory brainstem form axosomatic synapses that have advanced to one of the best-studied synaptic system of the mammalian brain. As the auditory system matures and adjusts to high fidelity synaptic transmis...
ORGANISM(S): Rattus norvegicus 
2014-06-24 | E-GEOD-49599 | biostudies-arrayexpress
ProteomicsMapping the dynamic high-density lipoprotein synapse
Background and aims: Heterogeneous high-density lipoprotein (HDL) particles, which can contain hundreds of proteins, affect human health and disease through dynamic molecular interactions with cell surface proteins. How HDL mediates its long-range signaling functions and interactions with various ce...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-17 | MSV000090734 | MassIVE
UnknownConical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone.
Not available
S-EPMC3844767 | biostudies-literature
UnknownElectrical synapse molecular diversity revealed by proximity-based proteomic discovery.
Not available
S-EPMC11601576 | biostudies-literature
TranscriptomicsLearned Helplessness Regulates Synapse Related LncRNAs in Mouse Hippocampus
Purpose: RNA sequencing (RNA-Seq) has revolutionized systems-based analysis of cellular pathways. The goal of this study is to find learned helplessness/depression regulates synapse related long noncoding RNAs (lncRNAs) in mouse hippocampus Methods: compared the differential expression of mRNA and l...
ORGANISM(S): Mus musculus 
2017-08-24 | GSE102965 | GEO
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