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MetabolomicsAntibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

Background

Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs t...

2020-09-28 | MTBLS1846 | MetaboLights
MetabolomicsRabbit plasma metabolomic analysis of Nitroproston: a multi target natural prostaglandin based-drug (Untargeted study)
INTRODUCTION: Nitroproston® is a novel multi-target drug bearing natural prostaglandin E2 (PGE2) and nitric oxide (NO)-donating fragments for treatment of inflammatory and obstructive diseases (i.e. asthma and obstructive bronchitis). OBJECTIVES: To investigate the effects of Nitroproston® adm...
2019-08-27 | MTBLS727 | MetaboLights
MetabolomicsDeciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

BACKGROUND: Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic ...

2021-08-03 | MTBLS981 | MetaboLights
TranscriptomicsAstrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis
Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve ad...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-61875 | biostudies-arrayexpress
MetabolomicsHealth outcomes of fruit juice and fruity beverage: a comparative analysis of gut microbiota and metabolomics in rats (Lipidomics assay)

BACKGROUND: Diet is foods and drinks regularly consumed, and its regulation is complicated. It is necessary to obtain a practical understanding of which foods and drinks contribute to health and well-being and which are insalubrious. Clear evidence shows that a high intake of fru...

2022-08-24 | MTBLS4108 | MetaboLights
MetabolomicsLC-HRMS Metabolomics for Untargeted Diagnostic Screening in Clinical Laboratories: A Feasibility Study
Today's high-resolution mass spectrometers (HRMS) allow bioanalysts to perform untargeted/global determinations that can reveal unexpected compounds or concentrations in a patient’s sample. This could be performed for preliminary diagnosis attempts when usual diagnostic processes and targeted ...
2019-06-06 | MTBLS476 | MetaboLights
TranscriptomicsExpression profiles of 186-gene signature in U.S. hepatitis C virus (HCV)-related liver cirrhosis
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54100 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of paired biopsies and explanted liver from hepatitis C virus (HCV)-infected individuals
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54101 | biostudies-arrayexpress
TranscriptomicsExpression profiles of 186-gene signature in Italian hepatitis C virus (HCV)-related liver cirrhosis
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54099 | biostudies-arrayexpress
TranscriptomicsA genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54102 | biostudies-arrayexpress
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