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ProteomicsEZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Efforts to therapeutically target EZH2 have generally focused on inhibition of its methyltransferase activity, although it remains less clear whether this is the central mechanism whereby EZH2 promotes cancer. We demonstrate that EZH2 directly interacts with both MYC family oncoproteins, MYC and MYC...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029652 | Pride
Mycn Ap-ms Myc Ezh2 
ProteomicsTherapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability
Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS) production which paradoxically damages DNA and free dNTPs. How these metabolic processes are integrated to fuel tumorigenesis remains to be ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD043444 | Pride
Myc Plk1 Nudt1 Cancer，protac 
UnknownChromosome-level assembly and analysis of three hydroxy fatty acid-producing Physaria species.
Not available
S-EPMC12749981 | biostudies-literature
ProteomicsFunctional analysis of Salix purpurea genes support roles for ARR17 and GATA15 as master regulators of sex determination
The Salicaceae family is of growing interest in the study of dioecy in plants because the sex determination region (SDR) has been shown to be highly dynamic, with differing locations and heterogametic systems across taxa. Previous studies investigating the mechanisms regulating sex in the genus Sali...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2023-02-01 | MSV000091180 | MassIVE
ProteomicsProteomics and network pharmacology of Ganshu Nuodan capsules in the prevention of alcoholic liver disease
A mouse model of acute alcohol liver disease (ALD) induced by intragastric administration of 50% alcohol was used to evaluate the hepatoprotective effect of Ganshu Nuodan. The chemical constituents of Ganshu Nuodan were comprehensively identified by UPLC-QTOF/MS, and then its pharmacodynamic materia...
ORGANISM(S): Mus Musculus 
2023-09-08 | PXD045221 |
ProteomicsExosomes from Cysticercus pisiforms induced proteome of rabbit peritoneal macrophages
Peritoneal macrophages from healthy New Zealand White rabbits were treated with exosomes from Cysticercus pisiforms and treated with PBS were used as control.
ORGANISM(S): Oryctolagus Cuniculus 
2022-04-21 | PXD033317 |
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