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ProteomicsDNAJC5 facilitates the proliferation and migration of lung adenocarcinoma cells by augmenting EGFR trafficking
Lung adenocarcinoma (LUAD) is a highly prevalent and lethal malignant tumor, with the aberrantly activated EGFR signaling pathway playing a crucial role in its development. However, resistance to tyrosine-kinase inhibitors (TKIs) targeting EGFR significantly limits the efficacy of LUAD clinical ther...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD063682 | Pride
Dnajc5 Ap2a1 Luad Egfr Endocytosis 
MetabolomicsEffect of Zanthoxylum bungeanum essential oil on rumen enzyme activity, microbiome, and metabolites in lambs

Antibiotics were once used in animal production to improve productivity and resistance to pathogenic microbiota. However, due to its negative effects, the search for a new class of substances that can replace its efficacy has become one of the urgent problems to be solved. Plant essential oils (E...

2022-09-13 | MTBLS3683 | MetaboLights
UnknownDe novo assembly and characterization of the root transcriptome of Aegilops variabilis during an interaction with the cereal cyst nematode.
Not available
S-EPMC3439707 | biostudies-literature
UnknownDehydration induced transcriptomic responses in two Tibetan hulless barley (Hordeum vulgare var. nudum) accessions distinguished by drought tolerance.
Not available
S-EPMC5637072 | biostudies-literature
UnknownQTL analysis in the Mianmai 902×Taichang 29 RIL population reveals the genetic basis for the high-yield of wheat cultivars Mianmai 902 in terms of spike and plant architecture.
Not available
S-EPMC11654426 | biostudies-literature
ProteomicsLipid mediated–phase separation of AGO proteins on the ER controls nascent peptide ubiquitination
we sought to determine whether dmAGO1 and Ltn1 share common ubiquitinated nascent peptide targets. For this purpose, we performed the UBA bead-based immunoprecipitation followed by mass spec experiments to identify the ubiquitinated nascent peptide targets of dmAGO1 and Ltn1, respectively. In this a...
ORGANISM(S): Drosophila Melanogaster 
2022-02-18 | PXD031749 |
ProteomicsCryptococcus neoformans LC-MS/MS
Cryptococcus neoformans is an invasive human fungal pathogen, which causes pneumonia and meningoencephalitis in both healthy and immunodeficient individuals, resulting 181,100 deaths each year. Studies have demonstrated that copper detoxification machineries play critical functions in modulating C. ...
ORGANISM(S): Cryptococcus Neoformans Var. Grubii H99 
2021-02-09 | PXD024098 |
ProteomicsArginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
m6A is the most abundant modification of mRNA in mammals and plays an important role in human development and disease. METTL14 is a key component of m6A methyltransferase complex. The project showed that its post-translational arginine methylation can regulate the generation of m6A and the endoderm ...
ORGANISM(S): Homo Sapiens 
2021-05-17 | PXD018458 |
ProteomicsHypoxia Regulates Overall mRNA Homeostasis by Inducing Met1-linked Linear Ubiquitination of AGO2 in Cancer Cells
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear. Here we show that hypoxia inhibits global-mRNA dec...
ORGANISM(S): Homo Sapiens 
2021-04-06 | PXD021722 |
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