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UnknownStrategies of laparoscopic spleen-preserving splenic hilar lymph node dissection for advanced proximal gastric cancer.
For advanced proximal gastric cancer (GC), splenic hilar (No. 10) lymph nodes (LN) are crucial links in lymphatic drainage. According to the 14(th) edition of the Japanese GC treatment guidelines, a D2 lymphadenectomy is the standard surgery for advanced GC, and No. 10 LN should be dissected for adv...
S-EPMC4919707 | biostudies-literature
UnknownA prospective international multisite randomized controlled trial of water exchange with and without distal cap(s) in adenoma detection.

Background

Interval cancers are linked to a low adenoma detection rate (ADR), prompting calls for benchmark-guided ADR performance improvement. Although water exchange and a straight cap (CAP) have been reported to independently improve ADR, the effects of Daisycuff™ and Endocuff ...
S-EPMC12850690 | biostudies-literature
UnknownCrosstalk between hypoxia-sensing ULK1/2 and YAP-driven glycolysis fuels pancreatic ductal adenocarcinoma development.
Autophagy and glycolysis are two catabolic processes that manipulate pancreatic ductal adenocarcinoma (PDAC) development in response to hypoxia sensing, yet the underlying mechanism of how they are interlinked remain elusive. Methods: The functional roles of Unc-51 like kinase 1 and 2 (ULK1/2...
S-EPMC8326115 | biostudies-literature
UnknownThe complete mitochondrial genome of <i>Ogmocotyle ailuri</i>: gene content, composition and rearrangement and phylogenetic implications.
Trematodes of the genus Ogmocotyle are intestinal flukes that can infect a variety of definitive hosts, resulting in significant economic losses worldwide. However, there are few studies on molecular data of these trematodes. In this study, the mitochondrial (mt) genome of Ogmocotyle ailur...
S-EPMC10410389 | biostudies-literature
UnknownRedox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications.
Colorectal cancer (CRC) is a common neoplastic disease and a frequent cause of death. Drug resistance is a major challenge to CRC treatment and stem-like side-population (SP) cells may play a key role in this resistance. Although it has been recognized that cancer stem cells may be affected by redox...
S-EPMC4893643 | biostudies-literature
UnknownAbsolute ranging over 113 km with nanometer precision.
Accurate long-distance ranging is crucial for diverse applications, including satellite formation flying, very-long-baseline interferometry, gravitational-wave observations, geographical research, etc. The integration of the time-of-flight measurement with phase interference in the dual-comb method ...
S-EPMC12629240 | biostudies-literature
ProteomicsUrinary proteomics analysis of active vitiligo patients
Vitiligo is a common acquired skin disorder caused by immune-mediated destruction of epidermal melanocytes. Systemic glucocorticoids (GCs) have been used to prevent the progression of active vitiligo, with 8.2%–56.2% of patients insensitive to this therapy. Currently, there is a lack of biomarkers t...
ORGANISM(S): Homo Sapiens 
2022-02-11 | PXD031595 |
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
ProteomicsCryo-EM Structures of ALECT2 Filaments from Human Renal Biopsies
The project aims to characterize the state of disulfide bond formation in recombinant LECT2 refolded under non-reducing conditions.
ORGANISM(S): Homo Sapiens 
2026-01-05 | PXD072679 |
UnknownThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia.

Background

In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, the mechanisms underlying hyperthermia resistance are still poorly understood. In this study, we investigated the roles of cold‑inducible RNA bi...
S-EPMC10903011 | biostudies-literature
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