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UnknownSuppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo.

Aim

To evaluate the impact of recombinant Bacteroides fragilis enterotoxin-2 (BFT-2, or Fragilysin) on colorectal tumorigenesis in mice induced by azoxymethane/dextran sulfate sodium (AOM/DSS).

Methods

Recombinant proBFT-2 was expressed in Escherichia coli strain Rosetta...
S-EPMC5292333 | biostudies-literature
UnknownUnpacking the cost implications of diagnosis-related groups reform for lumbar disc herniation patients in Chinese medicine: a closer look at evidence from China.

Objectives

Lumbar disc herniation (LDH) presents a significant economic burden globally, worsening in China due to an aging population. Traditional Chinese Medicine (TCM) offers effective treatment options for LDH, making its integration with Diagnosis-Related Groups (DRG) payment reform cru...
S-EPMC12491192 | biostudies-literature
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
UnknownColorectal cancer screening using a multi-locus blood-based assay targeting circulating tumor DNA methylation: a cross-sectional study in an average-risk population.

Background

Effective screening for colorectal cancer (CRC) enables earlier diagnosis and intervention to improve patient survival.

Methods

In this study, we prospectively conducted a blood-based CRC screening program for community residents in Hanjiang District, Yangzhou City, and eva...
S-EPMC11600563 | biostudies-literature
ProteomicsProteomic analysis of Emx1-G6PD CKO mouse cortex
To identify differentially expressed proteins in the cerebral cortex between control and Emx1-G6PD CKO mice
ORGANISM(S): Mus Musculus 
2025-07-22 | PXD066386 |
ProteomicsThe mechanism of ATP6V0A1 regulating immune evasion in colorectal cancer
Our previous study showed the immunosuppressive ability of colorectal cancer cell-intrinsic ATP6V0A1. This project aimed to understand the mechanism of ATP6V0A1 regulating immune evasion in colorectal cancer (CRC). For this purpose, we used MS analysis to detect the changes in the protein expression...
ORGANISM(S): Mus Musculus 
2024-06-11 | PXD044010 |
UnknownGenome-resolved metagenomics reveals microbiome diversity across 48 tick species.
Ticks are arthropod vectors capable of transmitting a wide spectrum of pathogens affecting humans and animals. However, we have relatively limited information of their genomic characteristics and the diversity of associated microbiomes. Here we used long- and short-read sequencing on 1,479 samples f...
S-EPMC12488481 | biostudies-literature
UnknownJoint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjuste...
S-EPMC4212832 | biostudies-literature
UnknownGenetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled genome-wide association studies summary statistics fr...
S-EPMC5697951 | biostudies-literature
UnknownAssociation analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differen...
S-EPMC6075203 | biostudies-literature
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