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In inflammatory diseases of the airway, a high level (estimated to be as high as 8 mM) of HOCl can be generated through a reaction catalyzed by the leukocyte granule enzyme myeloperoxidase (MPO). HOCl, a potent oxidative agent, causes extensive tissue injury through its reaction with various cellula...
ORGANISM(S): Homo sapiens 
proteome of LPS-stimulated macrophages in Il18-knockout mouse' liver and lung. proteome of LPS-stimulated macrophages in widetype mouse' liver and lung.
ORGANISM(S): Mus musculus (Mouse) 
2022-10-26 | PXD021657 | Pride
During mammalian pre-implantation embryonic development dramatic and orchestrated changes occur in gene transcription. The identification of the complete changes has not been possible until the development of the Next Generation Sequencing Technology. Here we report the first transcriptome dynamics...
ORGANISM(S): Bos taurus 
This project carried out a quantitative study of the target proteins that are lactylated and regulated by lactate levels in iWAT of HIIT mice. In order to ensure a high degree of credibility of the results, we quantitatively analyzed the changes in protein lactylation in three groups. Modification s...
ORGANISM(S): Mus <genus> 
2023-08-29 | PXD044919 |
Macrophages, locating in essentially all tissues, are critical for innate immune responses and involved in the tissue homeostasis. Distinct macrophages populations in different tissues exhibited diverse gene expressions and biological processes. Previous studies have accessed the molecular signature...
ORGANISM(S): Mus Musculus 
2022-10-28 | PXD021583 |
As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a TF DNA-binding activity centered multi-dimensional proteomics landscape, including DNA-binding activity of TFs, the p...
ORGANISM(S): Mus Musculus 
2018-06-25 | PXD008862 |
As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a TF DNA-binding activity centered multi-dimensional proteomics landscape, including DNA-binding activity of TFs, the p...
ORGANISM(S): Mus Musculus 
2018-06-25 | PXD008771 |
To explore the biological insights into squamous cell carcinoma (SCC) derived from different organs, we reported a deep proteomic analysis of 333 SCCs of 17 organs and 69 adenocarcinomas (ACs) of 7 organs. Proteomic comparison between pan-SCCs and pan-ACs identifies distinguishable pivotal pathways,...
ORGANISM(S): Homo Sapiens 
2022-05-19 | PXD033794 |
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