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ProteomicsProteome-wide profiling of Readers for DNA modification
Abstract DNA modifications, represented by methylcytosine (5mC), and its oxidized derivatives, such as hydroxymethylcytosine (5hmC), formylcytosine (5fC), and carboxylcytosine (5caC), play important roles in epigenetic regulation of biological processes. The specific recognition of DNA modifications...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-05-30 | PXD026362 |
ProteomicsRegion and cell-type resolved multi-omic altas of the heart
This work presented the panoramic heart proteome map, and served as the rich resource for heart researches in the future.
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus 
2025-02-17 | PXD060863 |
ProteomicsProteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies
Herein, we assembled a cohort composed of 254 CRC patients, including discovery cohort (N = 124) and validation cohort (N = 130), which received either chemotherapy (mainly FOLFOX therapy), chemoradiotherapy (mainly FOLFOX combined with radiotherapy), or targeted combination therapy (mainly FOLFOX c...
ORGANISM(S): Homo Sapiens 
2023-10-30 | PXD046566 |
ProteomicsIntegrated Plasma and Vegetation Proteomic Characterization of Infective Endocarditis for Early Diagnosis and Treatment
Infective endocarditis, a life-threatening condition, poses significant challenges for early diagnosis and personalized treatment due to insufficient biomarkers and limited understanding of its pathophysiology. Here, we analyzed plasma and vegetation proteomes from 238 patients with infective endoca...
ORGANISM(S): Homo Sapiens 
2025-04-06 | PXD062668 |
ProteomicsProteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets
In this study, we performed integrated multi-omics analyses using genomic (n = 79), transcriptomic (n = 42), proteomic (n = 224), and phosphoproteomic (n = 49) data collected from 224 samples from 168 patients with malignant and benign breast diseases. Our data revealed the characteristics of the li...
ORGANISM(S): Homo Sapiens 
2024-08-02 | PXD040750 |
ProteomicsProteogenomics of urothelial bladder cancer progression reveals the distinguished molecular features of different pathological subtypes
We reported a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 448 trace-tumor-samples from 190 urothelial bladder neoplasm patients, covering the whole spectrum of disease stages and grades. DNA damage was a...
ORGANISM(S): Homo Sapiens 
2023-08-02 | PXD043775 |
ProteomicsProteomics of Esophageal Squamous Cell Carcinoma Response to anti-PD1 Immunotherapy Response
Immunotherapy has revolutionized cancer treatment, yet many patients do not respond. Here, we profile the proteome and phosphoproteome of clinical pre-treatment samples from 73 esophageal squamous cell carcinoma (ESCC) patients undergoing anti-programmed death 1 (PD1) immunotherapy.
ORGANISM(S): Homo Sapiens 
2026-03-31 | PXD076423 |
ProteomicsComprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes
A comprehensive proteomic and genomic analysis of 438 trace tumor samples from 156 duodenal cancers, covering all 8 major histopathology stages of 2 major and 5 rare subtypes in 23 substages via pathological dissection.
ORGANISM(S): Homo Sapiens 
2022-12-16 | PXD038867 |
ProteomicsProteogenomic Characterization of Skull-base Chordoma
Skull-base chordoma (SBC) is a rare, aggressive bone cancer with a high recurrent rate. Genomic studies of SBC have improved our understanding of the disease’s biology. However, the molecular biological characteristics and the effective therapy of SBC remain unknown. Here, we carried out an integrat...
ORGANISM(S): Homo Sapiens 
2024-07-01 | PXD053550 |
ProteomicsProteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms
This dataset include the proteomic data of 243 glioma tumor tissues (discovery: 187, validation: 56); 56 tumor-adjacent tissues (discvoery: 35, validation: 21); 12 normal brain tissues; corresponding phosphoproteomic data
ORGANISM(S): Homo Sapiens 
2022-12-12 | PXD038732 |
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