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ProteomicsPCNA interactome - SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair
We examined the complexity of replication fork composition upon DNA damage by employing a PCNA-based proteomic screen to uncover known and new players involved in replication and replication stress response. We used camptothecin or ultraviolet radiation, that lead to fork-blocking lesions, to establ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-14 | PXD011727 | Pride
Pcna Bioid Interactome 
MetabolomicsHost-gut microbiota interactions shape parasite infections in farmed Atlantic salmon

Animals and their associated microbiota share long evolutionary histories. However, it is not always clear how host genotype and microbiota interact to affect phenotype. We applied a hologenomic approach to explore how host-microbiota interactions shape lifetime growth and parasite infection in f...

2024-01-24 | MTBLS8575 | MetaboLights
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
UnknownUbiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction.
Not available
S-EPMC4417291 | biostudies-literature
UnknownN<sup>6</sup>-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4.
Not available
S-EPMC11844294 | biostudies-literature
UnknownA Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.
Not available
S-EPMC8791798 | biostudies-literature
MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
MetabolomicsMetabolomics to elucidate the effects of novel sustainable feed additives in the feed of farmed salmon (HoloFood Trial B - blue mussel-dose response)

An experimental trial was conducted on juvenile farmed Atlantic salmon (Salmo salar) in the framework of the HoloFood project, which aims to test the effect of novel sustainable feed additives in the feed of farmed salmon. Trial B blue mussel was used as a novel sustainable protein feed source in...

2023-06-13 | MTBLS4382 | MetaboLights
MetabolomicsMetabolomics to elucidate the effects of novel sustainable feed additives in the feed of farmed salmon (HoloFood Trial A - seaweed-dose response)

Testing the effect of blue mussel ensilage as a novel cost-efficient protein feed source for Atlantic salmon feed. Fermentation of novel raw materials for fish feed is a new practice with little prior experience of direct relevance to aquaculture and fish farming. In Trial A, an alternative marin...

2023-06-13 | MTBLS4381 | MetaboLights
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