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ProteomicsBillon et al., PCNA acetylation dataset
This submission contains the mass spectrometry files for the manuscript by Billon et al. that identified key lysines residues within PCNA that control its functions. This submission contains 16 .raw and 16.dta files where a gel band containing PCNA was analyzed as well as 2 scaffold files used for s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000078851 | MassIVE
TranscriptomicsThe role of PCNA ubiquitylation during unperturbed genome replication in S.pombe
To establish if PCNA ubiquitylation affects the DNA replication kinetics of specific loci, we compared rates of DNA replication across the genome between rad18+ and rad18-delta cells using the BrdU-IP sequencing method. We mapped BrdU-incorporation at 300-bp resolution and subsequent informatics an...
ORGANISM(S): Schizosaccharomyces pombe 
2017-05-12 | E-GEOD-70033 | biostudies-arrayexpress
ProteomicsATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair
Mono-ubiquitinated PCNA (mono-Ub-PCNA) is generated when replication forks stall and facilitates the DNA lesion bypass process. After resolving a replication stall, Ub-PCNA needs to be de-ubiquitinated to resume high-fidelity DNA synthesis. ATAD5 cooperates with UAF1-USP1 to de-ubiquitinate mono-Ub-...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050108 | Pride
Baz1b De-ubiquitination Dna repair Usp1 Smarca5 Atad5 Baz1b Uaf1 Pcna 
ProteomicsPCNA interactome - SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair
We examined the complexity of replication fork composition upon DNA damage by employing a PCNA-based proteomic screen to uncover known and new players involved in replication and replication stress response. We used camptothecin or ultraviolet radiation, that lead to fork-blocking lesions, to establ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-14 | PXD011727 | Pride
Pcna Bioid Interactome 
GenomicsRNA-seq of PCNA WT/PyMT mammary tumor cell and PCNA 211F mammary tumor cell
RNA-seq of PCNA WT/PyMT mammary tumor cell and PCNA 211F mammary tumor cell
PRJNA632624 | ENA
ModelsAmara2013 - PCNA ubiquitylation in the activation of PRR pathway
Mechanistic model of the Post-Replication Repair (PRR), the pathway involved in the bypass of DNA lesions induced by sunlight exposure and UV radiation. PRR acts through two different mechanisms, activated by mono- and poly-ubiquitylation of the DNA sliding clamp, called Proliferating Ce...
2024-09-02 | BIOMD0000000475 | BioModels
ProteomicsNeutrophils display novel cytosolic proliferating cell nuclear antigen (PCNA) partners involved in interferon response in COVID-19
Neutrophils are key players in the hyperinflammatory response during SARS-CoV-2 infection, exhibiting features of deregulation and reprogramming. The cytosolic proliferating cell nuclear antigen (PCNA) is a scaffolding protein highly dependent on the microenvironment status and known to interact wit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055810 | Pride
Interferon Neutrophils Neutrophils extracellular traps Covid-19 Pcna 
ProteomicsG-CSF reshapes the cytosolic PCNA scaffold and modulates glycolysis in neutrophils
The balance between neutrophil survival and apoptosis must be tightly regulated to avoid exaggerated inflammatory responses. Cytosolic proliferating cell nuclear antigen (PCNA) is involved in neutrophil survival and function, where it acts as a scaffold and associates with proteins involved in NADPH...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD043496 | Pride
Pcna Neutrophil Survival G-csf Glycolysis 
ProteomicsPCNA and JNK1-Stat3 pathways respectively promotes and inhibits centrosome amplification by targeting at the ROCK1/14-3-3σ complex
We have recently reported that type 2 diabetes promotes cell centrosome amplification via enhancing the expression, biding and centrosome translocation of ROCK1/14-3-3σ complex. In the present functional proteomic study, we further investigated the molecular pathways underlying the centrosome amplif...
ORGANISM(S): Homo Sapiens 
2018-03-30 | PXD009370 |
GenomicsUbiquitinated PCNA drives USP1 synthetic lethality in cancer
Ubiquitinated PCNA drives USP1 synthetic lethality in cancer
PRJNA883979 | ENA
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