Sort   by:  
 Page size 
ProteomicsATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair
Mono-ubiquitinated PCNA (mono-Ub-PCNA) is generated when replication forks stall and facilitates the DNA lesion bypass process. After resolving a replication stall, Ub-PCNA needs to be de-ubiquitinated to resume high-fidelity DNA synthesis. ATAD5 cooperates with UAF1-USP1 to de-ubiquitinate mono-Ub-...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050108 | Pride
Baz1b De-ubiquitination Dna repair Usp1 Smarca5 Atad5 Baz1b Uaf1 Pcna 
ProteomicsATAD5 regulates R-loop by maintaining RNA helicase level and unloading PCNA at the replication fork
R-loops are formed when replicative forks collide with the transcriptional machinery and can cause genomic instability. However, it is unclear how R-loops are regulated at transcription-replication conflicts (TRC) sites and how replisome proteins are regulated to prevent R-loop formation or mediate ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018207 | Pride
Dead-box rna helicase Atad5 R-loop Replication stress Pcna 
UnknownATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair.
Not available
S-EPMC11615311 | biostudies-literature
UnknownPredisposition to cancer caused by genetic and functional defects of mammalian Atad5.
Not available
S-EPMC3161924 | biostudies-literature
UnknownDistinct Motifs in ATAD5 C-Terminal Domain Modulate PCNA Unloading Process.
Not available
S-EPMC9180478 | biostudies-literature
UnknownATAD5 deficiency alters DNA damage metabolism and sensitizes cells to PARP inhibition.
Not available
S-EPMC7229844 | biostudies-literature
UnknownATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress.
Not available
S-EPMC6914801 | biostudies-literature
UnknownThe human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader.
Not available
S-EPMC11563871 | biostudies-literature
UnknownATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork.
Not available
S-EPMC7367208 | biostudies-literature
UnknownShort-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombination.
Not available
S-EPMC10602867 | biostudies-literature
Sort   by:  
 Page size