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ProteomicsATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair
Mono-ubiquitinated PCNA (mono-Ub-PCNA) is generated when replication forks stall and facilitates the DNA lesion bypass process. After resolving a replication stall, Ub-PCNA needs to be de-ubiquitinated to resume high-fidelity DNA synthesis. ATAD5 cooperates with UAF1-USP1 to de-ubiquitinate mono-Ub-...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050108 | Pride
Baz1b De-ubiquitination Dna repair Usp1 Smarca5 Atad5 Baz1b Uaf1 Pcna 
TranscriptomicsChanges in gene expression in BAZ1B knockout and heterozygous targeted clones
Williams syndrome transcription factor (WSTF) is a multifaceted protein that is involved in several nuclear processes, including replication, transcription, and the DNA damage response. WSTF participates in a chromatin-remodeling complex with the ISWI ATPase, SNF2H, and is thought to contribute to t...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-47390 | biostudies-arrayexpress
GenomicsBAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the n...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-85005 | biostudies-arrayexpress
TranscriptomicsFunctional characterization of the role of the tyrosine-protein kinase BAZ1B in hormone- responsive breast cancer cells
Breast Cancer (BC) is one of the main causes of cancer-related death in women. The most widespread BC subtype (75%) is the hormone-dependent, characterized by high expression of Estrogen Receptor Alpha (ERa). ERa exerts its oncogenic activity through the interaction with different co-regulators, car...
ORGANISM(S): Homo sapiens 
2022-07-25 | E-MTAB-11142 | biostudies-arrayexpress
UnknownEvidence supporting the oncogenic role of BAZ1B in colorectal cancer.
Not available
S-EPMC9641411 | biostudies-literature
UnknownATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair.
Not available
S-EPMC11615311 | biostudies-literature
TranscriptomicsHaploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways
Williams syndrome (WS) is a neurodevelopmental disorder caused by a genomic deletion of ~28 genes that results in a cognitive and behavioral profile marked by overall intellectual impairment with relative strength in expressive language and hypersocial behavior. Advancements in protocols for neuron ...
ORGANISM(S): Homo sapiens 
2016-01-19 | GSE71664 | GEO
Unknownbaz1b loss-of-function in zebrafish produces phenotypic alterations consistent with the domestication syndrome.
Not available
S-EPMC9793288 | biostudies-literature
GenomicsFunctional characterization of the role of the tyrosine-protein kinase BAZ1B in hormone- responsive breast cancer cells
Functional characterization of the role of the tyrosine-protein kinase BAZ1B in hormone- responsive breast cancer cells
PRJEB48808 | ENA
GenomicsBAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the n...
ORGANISM(S): Mus musculus 
2016-07-30 | GSE85005 | GEO
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