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ProteomicsTargeted Protein Acetylation in Cells Using Heterobifunctional Molecules
Protein acetylation is a central event in orchestrating diverse cellular processes. However, current strategies to investigate protein acetylation in cells are often non-specific or lack temporal and magnitude control. Here, we developed an acetylation tagging system, AceTAG, to induce acetylation o...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD027617 | Pride
Targeted acetylation Acetylproteomics P300/cbp Heterobifunctional molecules 
TranscriptomicsMajor functional transcriptome of an inferred center regulator of an ER(-) breast cancer model system
We aimed to find clinically relevant gene activities ruled by the signal transducer and activator of transcription 3 (STAT3) proteins in an ER(-) breast cancer population via network approach. STAT3 is negatively associated with both lymph nodal category and stage. MYC is a component of STAT3 networ...
ORGANISM(S): Homo sapiens 
2012-09-25 | E-GEOD-32641 | biostudies-arrayexpress
TranscriptomicsIdentification of Prognostic Genes for Recurrent Risk Prediction in Triple Negative Breast Cancer Patients in Taiwan
Discrepancies in the prognosis of triple negative breast cancer exist between Caucasian and Asian populations. Yet, the gene signature of triple negative breast cancer specifically for Asians has not become available. Therefore, the purpose of this study is to construct a prediction model for recu...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-33095 | biostudies-arrayexpress
TranscriptomicsmicroRNA and mRNA expression profiles of human embryonic stem cells treated with activin A
Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self-renewal and pluripotency enable hES cells having the potential to provide an unlimited suppl...
ORGANISM(S): Homo sapiens 
2010-09-10 | E-GEOD-16910 | biostudies-arrayexpress
TranscriptomicsSIRT1 negatively regulates the differentiation of IL-9-producing CD4+T cells
Distinct metabolic programs support the differentiation of CD4+T cells into their separate lineages. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9 producing-CD4+T cells (TH9) in allergic airway inflammation and cancerous tumors. We found here that SIRT1 n...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-79607 | biostudies-arrayexpress
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
UnknownGenomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing.
Not available
S-EPMC5595870 | biostudies-literature
ProteomicsProteomic analysis of Fuzi and its processed products in treating Yang Deficiency Rats
The model rats of Yang deficiency syndrome were established by gavage of Huanglian and Dahuang and exhaustive swimming. The rats were treated with Fuzi, Yinfupian and Yangfupian. The liver tissue proteins were extracted and analyzed by TMT proteomics.
ORGANISM(S): Rattus Norvegicus 
2021-05-27 | PXD026321 |
TranscriptomicsEssential role of miR-200c in regulating self-renewal of breast cancer stem cells initiating from the counter parts of mammary epithelium
To explore the roles of essential miRNAs in regulating self-renewal of breast cancer stem cells (BCSCs), which initiate from mammary epithelial stem cells (MaSCs). CD44+CD24-/low cells and MUC1-ESA+ cells were isolated by fluorescence-activated cell sorting (FACS) from breast cancer cell line MCF-7 ...
ORGANISM(S): Homo sapiens 
2015-04-26 | E-GEOD-68271 | biostudies-arrayexpress
ProteomicsAn iTRAQ-based proteomics screen analysis of potential regulators of wheat (Triticum aestivum L.) root growth inhibition due to Al stress
Aluminum (Al)-induced root tip cell elongation inhibition is a major cause of plant root elongation suppression. Root tip cell elongation inhibition is caused by disruption to cell wall component metabolism, growth signaling, or cellular damage. The aim of this study was to identify the proteins inv...
ORGANISM(S): Triticum Aestivum Triticum Aestivum Subsp. Tibeticum 
2018-01-15 | PXD008684 |
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