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ProteomicsInvestigating HMGB1 as a Potential Serum Biomarker for Early Diabetic Nephropathy Monitoring by Quantitative Proteomics
Current diagnostic methods for diabetic nephropathy (DN) lack precision, especially in early stages and monitoring progression. This study aims to find potential biomarkers for DN progression and evaluate their accuracy. Using serum samples from healthy controls (NC), diabetic patients (DM), early-m...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD047872 | Pride
Diabetic nephropathy  serum proteomics  biomarker  progression  high mobility group protein b1 
UnknownSelection and validation reference genes for qRT-PCR normalization in different cultivars during fruit ripening and softening of peach (Prunus persica).
Not available
S-EPMC8012606 | biostudies-literature
MetabolomicsMulti-kingdom gut microbiota dysbiosis is associated with the development of pulmonary arterial hypertension

Gut microbiota dysbiosis has been implicated in pulmonary arterial hypertension (PAH). However, most studies have focused on the bacterial community and the exact role and mechanisms of multi-kingdom gut microbiota, including bacteria, archaea and fungi in PAH remains largely unclear. Idiopathic ...

2025-05-12 | MTBLS10563 | MetaboLights
TranscriptomicsSsu72 and Ser5P-RNAPII ChIPseq in hESCs. GROseq analysis in siCtrl and siSSu72 transfected hESCs.
Ssu72 is a Ser5P-RNAPII phosphatase, nevertheless few targets have been characterized and its role in mammal cells remains elusive. Using ChIPseq and GROseq technologies we aimed to identify Ssu72 targets in human embryonic stem cells. For the ChIPseq experiments, H1 hESCs growing in mTeSR media we...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-61393 | biostudies-arrayexpress
ProteomicsDIA-based proteomic analysis of barley seeds in response to salt stress
The purpose of this study was to analyze and research the differences in the mechanism of salt tolerance regulation in different germplasms of barley during seed germination. The agricultural production of barley (Hordeum vulgare L.) is affected by salinity stress due to the increasing problem of gl...
ORGANISM(S): Hordeum Vulgare 
2022-03-22 | PXD032701 |
UnknownOxygen Anion Redox Chemistry Correlated with Spin State in Ni-Rich Layered Cathodes.
Not available
S-EPMC10037688 | biostudies-literature
TranscriptomicsDeep sequencing and proteomics analysis reveal globally dysregulated expression of microRNA and their target genes in rat kidneys treated by carcinogenic dose of Aristolochic Acid
MicroRNAs (miRNAs) play an important role in carcinogenesis by regulating the protein translation from their targeted messenger RNAs (mRNA). Aristolochic Acid (AA) is a potent carcinogen that can induce kidney tumors in both human and experimental animals. Although the expression and roles of miRN...
ORGANISM(S): Rattus norvegicus 
2012-01-01 | E-GEOD-33703 | biostudies-arrayexpress
ProteomicsNuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease
We identify the Kcr sites on histones that are targeted by CDYL in ADPKD cells (WT9-12 cells). We chose to knock out CDYL in WT 9-12 cells (CDYL KO) through CRISPR/Cas9-mediated gene editing to increase the overall levels of histone Kcr. We quantified Kcr modifications on different histone residues ...
ORGANISM(S): Homo Sapiens 
2022-01-17 | PXD031029 |
TranscriptomicsExpression of microRNAs in rat kidney treated with a carcinogenic dose of Aristolochic Acid
Aristolochic Acid (AA), a natural component of Aristolochia plants found in a variety of herbal remedies and health supplements, is classified as a group 1 carcinogen by the International Agency for Research on Cancer. In order to search for miRNA regulation in AA-induced carcinogenesis, we treated ...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-54338 | biostudies-arrayexpress
Proteomics[HPP-2.0] Prostate cancer specific library including 125 injections
prostate cancer FFPE samples includes 125 injections
ORGANISM(S): Homo Sapiens 
2024-02-01 | PXD049071 |
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