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ProteomicsIn-situ Click Reaction Coupled with Quantitative Proteomics for Identification of Protein Targets of Catechol Estrogens
Catechol estrogens (CEs) are metabolic electrophiles that actively undergo covalent interaction with cellular proteins, influencing molecular function. There is no feasible method to identify their binders in a living system. Herein, we developed a click chemistry-based approach using ethinylestradi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-28 | PXD009657 | Pride
Post translational modification Metabolites Proteomics Electrophiles Dimethyl labeling Lc/ms Catechol estrogens Oxidative stress Click chemistry Redox modification 
ProteomicsIdentification of Cytosolic Protein Targets of Catechol Estrogens in Breast Cancer Cells Using a Click Chemistry-based Workflow
Catechol estrogens (CEs) are known to be toxic metabolites and the initiators in the oncogenesis of breast cancers via forming covalent adducts with DNAs. CEs shall also react with proteins but their cellular protein targets remain un-explored. Here we reported the identification of protein targets ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD017731 | Pride
Affinity purification Catechol estrogens Breast cancer cells Mass spectrometry Proteomic 
UnknownSARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1.
Not available
S-EPMC9177730 | biostudies-literature
ProteomicsHydrogen sulfide mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small-cell lung cancer
Ferroptosis, a novel form of regulated cell death triggered by the iron-dependent peroxidation of phospholipids, offers promising penitential for cancer therapy. Hydrogen sulfide (H2S), an endogenous metabolite of the transsulfuration pathway, has been implicated in ferroptosis. However, the precise...
ORGANISM(S): Homo Sapiens 
2023-12-04 | PXD047493 |
UnknownTranscriptome changes affecting Hedgehog and cytokine signalling in the umbilical cord: implications for disease risk.
Not available
S-EPMC3393728 | biostudies-literature
UnknownAssociation Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Not available
S-EPMC5638008 | biostudies-literature
UnknownGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Not available
S-EPMC3969612 | biostudies-literature
UnknownAssociation analysis identifies 65 new breast cancer risk loci.
Not available
S-EPMC5798588 | biostudies-literature
UnknownThe power of genetic diversity in genome-wide association studies of lipids.
Not available
S-EPMC8730582 | biostudies-literature
UnknownImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Not available
S-EPMC9793579 | biostudies-literature
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