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ProteomicsM1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
In order to identify more gypsy insulator interactors, we performed immunoaffinity purification of Drosophila embryonic nuclear extracts using antibodies specific for CP190 and analyzed the eluates using quantitative mass spectrometry.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-06-07 | PXD026493 | Pride
Mass spectrometry Drosophila Cp190 Embryonic nuclear extract 
ProteomicsM1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
Genome organization is driven by forces affecting transcriptional state, but the relationship between transcription and genome architecture remains unclear. Here, we identified the Drosophila transcription factor Motif 1 Binding Protein (M1BP) in physical association with the gypsy chromatin insulat...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-06-07 | PXD026497 | Pride
Embryo Mass spectrometry Drosophila Nuclear extract Su(hw) 
ProteomicsNURF301 contributes to gypsy chromatin insulator-mediated nuclear organization
Chromatin insulators are DNA-protein complexes that can prevent the spread of repressive chromatin and block communication between enhancers and promoters to regulate gene expression. In Drosophila, the gypsy chromatin insulator complex consists of three core proteins: CP190, Su(Hw), and Mod(mdg4)67...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-14 | PXD032165 | Pride
Mass spec Nurf301 Drosophila Gypsy insulator 
ProteomicsThe AMBRA1 E3 ligase adaptor regulates Cyclin D protein stability
Here we describe AMBRA1 as the main regulator of Cyclin D protein degradation. We first identify AMBRA1 as the top candidate in a genome-wide CRISPR/Cas9 loss-of-function screen investigating the genetic basis of resistance to chemical CDK4/6 inhibition. AMBRA1 loss results in high protein levels of...
ORGANISM(S): Homo sapiens (Human) 
2021-07-24 | PXD021789 | Pride
Human Cancer Cyclin d Cell cycle 
UnknownAnxiety and depressive symptoms in college students during the late stage of the COVID-19 outbreak: a network approach.
Not available
S-EPMC8678580 | biostudies-literature
ProteomicsThe AMBRA1 E3 ligase adaptor regulates Cyclin D protein stability
Ubiquitylation proteomics experiment for HEK293T cells treated with either non-targeting shRNA, or shRNA knockdown of AMBRA1 by two independent shRNA's (shAMBRA1-TRC20, and shAMBRA1-TRC36).
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD022111 | Pride
Orbitrap elite Ubiquitin Human 
UnknownApolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids.
Not available
S-EPMC8500881 | biostudies-literature
UnknownCell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease.
Not available
S-EPMC11980647 | biostudies-literature
UnknownThe AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.
Not available
S-EPMC8246597 | biostudies-literature
UnknownAlzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.
Not available
S-EPMC7388065 | biostudies-literature
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