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ProteomicsUbiquitin Ligase Enzyme FANCL Inhibits Peste des petits ruminants Virus Replication by Inducing Type I Interferon Production through Promoting Phosphorylation of TBK1
Peste des petits ruminants virus (PPRV) infection causes highly contagious and severe disease in domestic and wild ruminants. It is widely reported that PRRV infection causes considerable innate immunosuppression in its host and promotes viral replication. However, how does the host rescue the innat...
ORGANISM(S): Ovis aries 
2021-07-26 | PXD022271 | Pride
Peste des petits ruminants virus  quantitative proteomics  fancl  innate immune response  tbk1 
ProteomicsThe insufficient activation of RIG-I-like signaling pathway in IBRS-2 cells contributes to highly efficient replication of porcine picornaviruses
Seneca Valley Virus (SVV) or commonly known as Senecavirus A (SVA), is one of picornavirus that is associated with vesicular disease and neonatal mortality in swine herds. However, the pathogenesis of SVV remains largely elusive. Our previous study found that SVV replicates extremely faster in porci...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-10-05 | PXD024003 | Pride
Senecavirus a  foot-and-mouth disease virus  rig-i like receptor signaling pathway  interferon  antiviral response 
ProteomicsThe insufficient activation of RIG-I-like signaling pathway in IBRS-2 cells contributes to highly efficient replication of porcine picornaviruses
Seneca Valley Virus (SVV) or commonly known as Senecavirus A (SVA), is one of picornavirus that is associated with vesicular disease and neonatal mortality in swine herds. However, the pathogenesis of SVV remains largely elusive. Our previous study found that SVV replicates extremely faster in porci...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-10-05 | PXD024002 | Pride
Senecavirus a  foot-and-mouth disease virus  rig-i like receptor signaling pathway  interferon  antiviral response 
ProteomicsNeofusiccocum parvum mycelium LC-MS/MS
TMT quantitative proteome of BH01 and BH03 of two Neofusiccocum parvum strains under different culture conditions
ORGANISM(S): Neofusicoccum Parvum 
2022-06-03 | PXD034277 |
ProteomicsProteomic and Acetylome Alterations in Obesity-related Osteoarthritic Mouse Cartilage
Male mice aged 4 weeks were housed under controlled conditions and assigned to either a normal diet or a high-fat diet for 16 weeks to establish an obesity model. At 12 weeks, osteoarthritis was induced using the destabilization of the medial meniscus procedure under anesthesia, while sham-operated ...
ORGANISM(S): Mus Musculus 
2025-04-08 | PXD062707 |
ProteomicsPeste des petits ruminants virus nucleocapsid protein interacts with PACT and induces stress granule to promote viral replication
Stress granules (SGs) formation is a conserved cellular strategy to reduce stress-related damage regulating cell survival. A Mass spectrometry-based profiling of the interactome of PPRV N protein revealed that PPRV N interacted with PACT to regulate the assembly of SGs. N protein inhibited the inter...
ORGANISM(S): Homo Sapiens 
2022-12-27 | PXD039104 |
ProteomicsA multi-omics dataset of human transcriptome and proteome stable reference
In recent years, the development of high-throughput omics technology has greatly promoted the development of biomedicine. However, the poor reproducibility of omics techniques limits its application. It is necessary to use standard reference materials of complex RNAs or proteins to test and calibrat...
ORGANISM(S): Homo Sapiens 
2023-04-03 | PXD041292 |
ProteomicsARIH1 Signaling Promotes Anti-tumor Immunity by Targeting PD-L1 for Proteasomal Degradation
We find EGFR inhibitors promote PD-L1 ubiquitination and proteasomal degradation following GSK3α-mediated phosphorylation of Ser279/Ser283.
ORGANISM(S): Homo Sapiens 
2021-03-01 | PXD024452 |
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