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ProteomicsTIGAR Regulates Intestinal Mucus Barrier Integrity by Inhibiting Lactylation of G6PD/6PGD in Ulcerative Colitis
Oxidative stress and metabolic dysregulation in goblet cells represent significant contributors to the pathogenesis of ulcerative colitis (UC). TIGAR (TP53-induced glycolysis and apoptosis regulator) plays a critical role as a metabolic regulatory enzyme by promoting NADPH synthesis, thereby counter...
ORGANISM(S): Homo sapiens (Human) 
2026-01-29 | PXD069158 | Pride
Tigar  lactylation  6pgd  g6pd  ulcerative colitis 
UnknownHigh-Fat Diet Increases Amylin Accumulation in the Hippocampus and Accelerates Brain Aging in hIAPP Transgenic Mice.
Not available
S-EPMC6718729 | biostudies-literature
UnknownLandscape of X chromosome inactivation across human tissues.
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S-EPMC5685192 | biostudies-literature
UnknownNeuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats.
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S-EPMC9162172 | biostudies-literature
UnknownGeneration of hiPSCs with ABO c.767T>C substitution: resulting in splicing variants.
Not available
S-EPMC10310534 | biostudies-literature
UnknownC/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation.
Not available
S-EPMC5928165 | biostudies-literature
MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
UnknownUnveiling tryptophan dynamics and functions across model organisms via quantitative imaging.
Not available
S-EPMC11562630 | biostudies-literature
UnknownComparing PET/MRI with PET/CT for Pretreatment Staging of Gastric Cancer.
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S-EPMC6378050 | biostudies-literature
UnknownProbing CP symmetry and weak phases with entangled double-strange baryons.
Not available
S-EPMC9159954 | biostudies-literature
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