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TranscriptomicsRNA-seq of human cancer cell line OVCA420* following TIGAR knockdown with shRNA
To identify differentially expressed genes following TIGAR knockdown, OVCA420* was transduced with TIGAR-targeting or non-targeting (control) shRNAs. 54 hours after the transduction, RNA was extracted and Illumina TruSeq RNA Sample Preparation Kit v2 was used to prepare the libraries. Each group con...
ORGANISM(S): Homo sapiens 
2018-10-24 | E-MTAB-7284 | biostudies-arrayexpress
ProteomicsTIGAR Regulates Intestinal Mucus Barrier Integrity by Inhibiting Lactylation of G6PD/6PGD in Ulcerative Colitis
Oxidative stress and metabolic dysregulation in goblet cells represent significant contributors to the pathogenesis of ulcerative colitis (UC). TIGAR (TP53-induced glycolysis and apoptosis regulator) plays a critical role as a metabolic regulatory enzyme by promoting NADPH synthesis, thereby counter...
ORGANISM(S): Homo sapiens (Human) 
2026-01-29 | PXD069158 | Pride
Tigar  lactylation  6pgd  g6pd  ulcerative colitis 
ProteomicsTIGAR Regulates Intestinal Mucus Barrier Integrity by Inhibiting Lactylation of G6PD/6PGD in Ulcerative Colitis
Oxidative stress and metabolic dysregulation in goblet cells represent significant contributors to the pathogenesis of ulcerative colitis (UC). TIGAR (TP53-induced glycolysis and apoptosis regulator) plays a critical role as a metabolic regulatory enzyme by promoting NADPH synthesis, thereby counter...
ORGANISM(S): Homo Sapiens 
PXD069246 |
GenomicsRNA Sequencing Analysis of vascular smooth muscle cell from Wild Type and TIGAR-/- mice
RNA Sequencing Analysis of vascular smooth muscle cell from Wild Type and TIGAR-/- mice
PRJNA1297162 | ENA
GenomicsRNA Sequencing Analysis of bone marrow derived macrophages from Wild Type and TIGAR-/- mice
RNA Sequencing Analysis of bone marrow derived macrophages from Wild Type and TIGAR-/- mice
PRJNA836125 | ENA
GenomicsRNA-seq of human cancer cell line OVCA420* following TIGAR knockdown with shRNA
RNA-seq of human cancer cell line OVCA420* following TIGAR knockdown with shRNA
PRJEB29129 | ENA
TranscriptomicsRNA Sequencing Analysis of vascular smooth muscle cell from Wild Type and TIGAR-/- mice
We identified that global TIGAR deficiency inhibited VSMC dedifferentiation. The purpose of this experiment was to identify how TIGAR inhibited VSMC dedifferentiation.We then performed gene expression profiling analysis using data obtained from RNA-seq of VSMC from WT and TIGAR KO mice stimulated wi...
ORGANISM(S): Mus musculus 
2025-08-26 | GSE303726 | GEO
TranscriptomicsRNA Sequencing Analysis of bone marrow derived macrophages from Wild Type and TIGAR-/- mice
We identified that global TIGAR deficiency reduced the AS plaque formation and the systemic inflammatory response. The purpose of this experiment was to identify how TIGAR induces macrophage inflammation.We then performed gene expression profiling analysis using data obtained from RNA-seq of bone ma...
ORGANISM(S): Mus musculus 
2024-04-06 | GSE202446 | GEO
TranscriptomicsNuclear TIGAR mediates an epigenetic-metabolic loop via Nrf2 for cancer therapeutics resistance
Epigenetic and metabolic reprogrammings are implicated in cancer progression with unclear mechanisms. We report here that the histone methyltransferase NSD2 drives cancer cell and tumor resistance to therapeutics such as tamoxifen, doxorubicin, and radiation by reprogramming of glucose metabolism. N...
ORGANISM(S): Homo sapiens 
2016-10-22 | GSE62613 | GEO
TranscriptomicsNuclear TIGAR mediates an epigenetic-metabolic loop via Nrf2 for cancer therapeutics resistance
Epigenetic and metabolic reprogrammings are implicated in cancer progression with unclear mechanisms. We report here that the histone methyltransferase NSD2 drives cancer cell and tumor resistance to therapeutics such as tamoxifen, doxorubicin, and radiation by reprogramming of glucose metabolism. N...
ORGANISM(S): Homo sapiens 
2016-10-22 | E-GEOD-62613 | biostudies-arrayexpress
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