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TranscriptomicsDNA microarrays of Turner Syndrome induced pluripotent stem cells
We have generated iPSCs from monosomy X (Turner Syndrome), trisomy 8 (Warkany Syndrome 2), trisomy 13 (Patau Syndrome) and partial trisomy 11;22 (Emanuel Syndrome), using either skin fibroblasts from affected individuals or amniocytes from antenatal diagnostic tests. These cell lines stably maintain...
ORGANISM(S): Homo sapiens 
2011-10-03 | E-GEOD-32527 | biostudies-arrayexpress
TranscriptomicsWheat Yr5 isolines treated with P.s. tritici PST-100 (06-194)
Comparison of 2 P. s. tritici-inoculated and mock-inoculated isolines that differ for the putative Yr5 resistance gene over a time course (6, 12, 24, 48h) ****[PLEXdb(http://www.plexdb.org) has submitted this series at GEO on behalf of the original contributor, Tristan Coram. The equivalent exp...
ORGANISM(S): Triticum aestivum 
2011-08-30 | E-GEOD-31753 | biostudies-arrayexpress
TranscriptomicsWheat Yr39 and yr39 (Alpowa) genotypes treated with P.s. tritici PST-78
Comparison of 2 P. s. tritici-inoculated and mock-inoculated genotypes that differ for the Yr39 high-temperature adult-plant resistance phenotype over a time course (12, 24, 48h) ****[PLEXdb(http://www.plexdb.org) has submitted this series at GEO on behalf of the original contributor, Tristan Co...
ORGANISM(S): Triticum aestivum 
2011-08-30 | E-GEOD-31756 | biostudies-arrayexpress
UnknownWhole-genome sequencing of Puccinia striiformis f. sp. tritici mutant isolates identifies avirulence gene candidates.
Not available
S-EPMC7085141 | biostudies-literature
UnknownIdentification of key hub genes in knee osteoarthritis through integrated bioinformatics analysis.
Not available
S-EPMC11439059 | biostudies-literature
TranscriptomicsComparative analysis of transcripts associated with all-stage resistance to stripe rust in wheat
Stripe rust, caused by Puccinia striiformis f. sp. tritici, is a destructive disease of wheat worldwide. Genetic resistance is the preferred method for controlling stripe rust, of which two major types are race-specific and race non-specific resistance. Race-specific resistance includes the qualitat...
ORGANISM(S): Triticum aestivum 
2010-05-19 | E-GEOD-13346 | biostudies-arrayexpress
ProteomicsEvaluation of library-free strategies for phosphoproteomics and ubiquitinomics data-independent acquisition data
Phosphoproteomics and ubiquitinomics data-independent acquisition MS data is generally analyzed using a DDA spectral library. Performance of different library-free strategies of analyzing phosphoproteomics and ubiquitinomics DIA MS data are not evaluated. In this study, we assess three library-free ...
ORGANISM(S): Homo Sapiens 
2023-05-17 | PXD037870 |
ProteomicsHK1 from HSC-derived extracellular vesicles promotes HCC progression
Extracellular vesicles play crucial roles in intercellular communication in tumor microenvironment. Here, we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracellula...
ORGANISM(S): Homo Sapiens 
2022-08-09 | PXD035911 |
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-09-16 | PXD056134 |
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