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ProteomicsHipk4 is a manchette-associated protein essential for spermiogenesis
Nonobstructive azoospermia (NOA) is one of the most severe forms of male infertility, characterized by the absence of spermatozoa in the ejaculate. The etiology and genetic mechanism(s) of this disease remain largely unclear. Using Sanger sequence, we identified 12 heterozygous missense mutations an...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD019303 | Pride
Hipk4 Spermiogenesis Mouse 
ProteomicsProteomic analysis of Dpy19l2-deficient human globozoospermia reveals multiple molecular defects
Globozoospermia is a severe teratozoospermia characterized by round-headed spermatozoa without acrosomes, resulting in male infertility. The clinical treatment of globozoospermia involves primarily intracytoplasmic sperm injection because of the low fertilization rate. The deletion of Dpy19l2 is kno...
ORGANISM(S): Homo sapiens (Human) 
2019-08-15 | PXD012302 | Pride
Proteomics Dpy19l2 Human Globozoospermia Round-headed 
ProteomicsEnergy-translation coupling limits yeast anaerobic growth
This study employs yeast as a model system to thoroughly investigate the differences in regulatory mechanisms under various nutrient limitation conditions, utilizing a systems biology approach integrated with techniques such as multi-omics analysis.To obtain a comprehensive quantitative landscape of...
ORGANISM(S): Staphylococcus Aureus 
2026-05-28 | PXD078963 |
ProteomicsRNA-Binding Motif protein 6 is a candidate serum biomarker for pancreatic cancer
Early diagnosis is crucial to improve outcomes for pancreatic cancer (PC) patients, however the lack of specific and validated biomarkers for the disease remains challenging. In this study, we analyzed the serum proteome of 12 PC patients and 76 healthy controls (HC), using magnetic bead-based weak ...
ORGANISM(S): Homo Sapiens 
2019-04-25 | PXD013626 |
ProteomicsPorphyromonas gingivalis infection and atherosclerosis
To explore the effect of Porphyromonas gingivalis on lipid-laden macrophages, the project was conduct. Overall design: 8 samples, 4 replicates in 2 groups, with ox-LDL-treated RAW264.7 macrophages stimulated with or without Porphyromonas gingivalis.
ORGANISM(S): Mus Musculus 
2024-01-09 | PXD048371 |
ProteomicsThe role of Ptpn11E76K in MSC fate determination
MSCs expressing Ptpn11+/+ or Ptpn11E76K/+ were lysed for proteomic analysis. In brief, 0.5 μg of peptide mixture resolved in buffer A (0.1% formic acid) was loaded onto a 2‒cm self‒packed trap column using buffer A and separated on a 150 μm‒inner‒diameter column with a length of 15 cm over a 78‒min ...
ORGANISM(S): Mus Musculus 
2023-02-28 | PXD040487 |
ProteomicsProteome profiling of Houttuynia cordata Thunb
Proteome profiling of different tissue of Houttuynia cordata Thunb.
ORGANISM(S): Arabidopsis Thaliana 
2023-01-11 | PXD039358 |
Proteomicsproteomics of synaptosomal crude extracts of AD
analyze the proteomics of synaptosomal crude extracts of AD
ORGANISM(S): Homo Sapiens 
2026-08-10 | PXD082398 |
ProteomicsPhosphoroteome of Scutellaria baicalensis
3289 phosphopeptides were identified and mapped to 1472 proteins that are comparable by phosphoproteomics analysis and annotated in COG/KOG, Domain, KEGG and GO database, respectively
ORGANISM(S): Scutellaria Baicalensis 
2023-04-18 | PXD041603 |
ProteomicsProteome of Scutellaria baicalensis Georgi
Proteome of Scutellaria baicalensis Georgi from multiple tissues
ORGANISM(S): Scutellaria Baicalensis 
2023-04-18 | PXD041602 |
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